APL1/YJR005W Protein Information Help

Standard Name Apl1p
Systematic Name Yjr005wp
Alias Yap80p
ORF Classification Verified
Description Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex (1, 2, 3, 4)
Name Description clathrin Adaptor Protein complex Large chain
Experimental Data
Molecules/cell 1670 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 700
Molecular Weight (Da) 80,453
Isoelectric Point (pI) 6.36

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Apl1p (InterPro)
Physical Interactions There are 25 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530A6 | P27351
MIPS: YJR005W
NCBI: 1015628 | 1168342 | 173202 | 398364751 | 854578 | NP_012538.3 | NM_001181662.3
GenBank/EMBL/DDBJ: AAA35226.1 | CAA60927.1 | CAA89527.1 | DAA08795.1 | M64998 | X87611 | Z49505
Amino Acid Sequence (or in FASTA format)
       1  MSDQKVFARY KANEIVTDLQ HFGVKKFKSN ITRRKNALRK IIANLVLGNY
      51  GEMSVLFSEL LKFWQIEDDL EVKRICHEYI RVIGALKPQQ AREALPFIMD
     101  DFKSRDEKLQ IMALRTLVLV PVKELSDQAF DCIISLVNHK SPPEQVTRTA
     151  IYALLDLDEI DHERVLGLSS ILHDIVKAQS SSPEVIVAAL HTLYSIHEKN
     201  ANMEPFRIPL ELAFDMLELL PELNEWNKAT VLEVLTTSVV PQHYLDTHEM
     251  IELALPYLQQ VNTYVVLNSL KFIMYLLNYV DVIKETLAEK LSNSVIALLD
     301  KPPELQFLVL RNVILLLLSR ESSLLRLDIS YFFIEYNDPI YIKDTKLECL
     351  YLLANKETLP RILEELEQYA TDIDIQMSRK SVRAIGNLAV KLDEDSVHDC
     401  VAVLLDLLEF GVDYVVQEII SVFRNILRKY PNNFKANVTE LVKHTEVVQE
     451  PESKNAMIWI ITQYSDVIPN YLELFRVFSS NMFSETLEVQ FSILNSAIKF
     501  FIRSPTKETE ELCMDLLKGC IDHENNPDLR DKTLMYWRLL SLTKTSRISN
     551  AITFESLKSV LDGELPLIEM NTKLDPTVLE ELELNIGTIV SIYLKPVSHI
     601  FRLNKTKLLP QSPILNPNKD LLPVVGNSFP PTGANRDRQN SESQSSTKSR
     651  KTAMMDDYDK PAEKINQLKG KRKSSSNNPS KLSRKPSTLL RKLSMKRPFS
     701  *                                                     

external links for Apl1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Apl1p
1) Rad MR, et al.  (1995) Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci 108 ( Pt 4)():1605-15
2) Kirchhausen T  (1990) Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes. Mol Cell Biol 10(11):6089-90
3) Kirchhausen T  (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98
4) Yeung BG, et al.  (1999) Adaptor complex-independent clathrin function in yeast. Mol Biol Cell 10(11):3643-59
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41