LAA1/YJL207C Protein Information

Standard Name	Laa1p 1
Systematic Name	Yjl207cp
ORF Classification	Verified
Description	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene (1, 2, 3, 4)
Name Description	Large AP-1 Accessory 1

Experimental Data
Molecules/cell	300 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	2,014
Molecular Weight (Da)	229,898
Isoelectric Point (pI)	5.52

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Laa1p (InterPro)
Physical Interactions	There are 19 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B60B \| P39526 MIPS: YJL207C NCBI: 1015587 \| 496955 \| 547583 \| 6322254 \| 731942 \| NP_012328.1 GenBank/EMBL/DDBJ: DAA08603.1 \| X77688 \| Z34098 \| Z49482

Amino Acid Sequence (or in FASTA format)
1 MANRSLKKVI ETSSNNGHDL LTWITTNLEK LICLKEVNDN EIQEVKEIHT 51 QLDEFVRYIS VLENTDDLEL HSVFISLSQL YTISIWRLKD EYPGVVFDSA 101 AFLTNVLCEE DVSIDDGDTD PNQKKKKKKS STKKKKYIYS PAKDIACTIL 151 VQLFENFGSS ISSLIPLLFN AIFKNLKKIM EKSKYYHATF MTTLLQLFNA 201 ILRNSNNDDK ILDPATYAKF SKLSKTVFDS ISTDEKDFSV TFVSVLIECW 251 TAHFKQTNFI REHSHDIIET IYSRFTEGEI GVYGFANDET RIFTAKSLAE 301 ILFDYYFSKN ILTLQEVWSI YVKIFLNCDT RDVESGCFES IIHLINLNLL 351 ADNTFLSNSK YLDIVLSLSG VFSSYEVNNR SMNTLSRYLR YFQHMHEVIL 401 PHLNDSAKTQ MLYYILGCSD TYQSSSKSDS ASNFKYSIDA KPETQWLTLL 451 QLDFTYVLIS DLGSTFTTEE NTVKEIRDKL VDLATCEIFT IRVHTVEILK 501 VFLNNCPEYL SETIENSLRA LSTDFKSTGK FIFHKNHGHA FIIANLIKGA 551 ESDYISYELI MRITVFSTSF IKNNTTSTSS NLYFKGLLCW ILLIGLMNYK 601 DEQYLKLQIP QLFLFWKVLL THTYTYHDED ELYKNLEIRN HALTCLLTYL 651 SNTTIDKEMA KQVSYLLTKC SNFNHSIDLK SKNIDNALLH NENRILQVYL 701 KLEKYINSDF NSSLLILIVK NFSDPNLYTE SSSSVLGSLK DIGNRKVSNK 751 DDMESNIVLE SSINTLLRQN NGFAFGLSSK ITGDRIVNLS MSSAYKYDES 801 ISGSWPSKDY NWYNIFEVEV SKPISPILSL DSLILLYGSG SYSQIDRYAP 851 QVTTSLIDSS MELFSSVFPF LNSKIQYSIM ETLNLSMFSK MTTPLRSVAV 901 AANVCSALHN ALRIMQENNL ELDYSVGQLI IESIKKIQFF NDIFLTKIKA 951 DCVGLLTAAI ARTLGDEERQ KFLTEQSRIF IKNVADMDEP YLRMFHVLSL 1001 ATIFKYNSQY ANFEEYFDVI FALMRDPHPV VHSWSLKAMH ILLEKHLVID 1051 LKTAALLLSS MEELLVQDKY GIYGRSTLRC NYNRDFNSHV AIGEISRTLT 1101 ETVGPNFLEL NTKVLDSFRN ITLSMLISNN ILNSITSIKM FENIATFKMK 1151 NILNYEIFIL ASKSIIKSSI VTGIGSSYFD TTFTGSNELI SRTSSLKGAF 1201 ENFDLLTLLY KLQMEEFFMK EMENLSWRYL ALFPNSGSVK NYFTEWILHT 1251 FKRDNHWFDK LYSIFNMSLG RLFQSYNRDV SALLEVNGLK KSSEKEIKGE 1301 EEESIANVNQ LTDTDAGGLD SENLQWKSRQ IILNLILMLC LESEKYENLL 1351 LALSNKIADL IKISFRGSTV RNEGMKLTGL HILNFVLKNY STMRDPQVPG 1401 SSILEQQEAQ ITSALMPAFS KGSSPTVMSF AITVAAEVLA SNIMPPDKLG 1451 RISQLLIDLL GNFKDPNSGI RIGEAIIVTP KAKRKIELAV LDAWAEVVQR 1501 SITSSNDALF SFTRKYWSIL VPLWIISLRE YMMIKYNDND STVQVKNDSK 1551 ENSLIEPRST KIELYEPVWL NFVEALGCTL DSDVQVILAS LNDEELEYFL 1601 FILFSQCLEA IVKNIDDHSV KMQVLPALHN VLKSNLCIKS IFEDDIITEV 1651 VEIMDRLIST GDSKEEFLLV DIISDLIIGY SKCNATPETF LQDIDKLYEL 1701 LRLLMTIISE RLPFIKYNVL TSEEDDNEIK ISPTDISLLK KTFIAFESNI 1751 SNFDNMFKVD LYSCLLFIIG KIYECSHREV IIPIILPLFK ALVKALTESE 1801 DEKNIVLLEI FYGSIKDVIY HKLDSKNKVA TILILLSNGY SKLSFQELNQ 1851 CANILSEALN NPATQPIALQ GFKRIISNIF KYPLLQYFMK LVIKRFFQDI 1901 QTNDSLSQAS IKTKLIIQFS EEVIKQDHQK ASLSIALCLS FFAAYHSAYT 1951 EKIDNEVASG IVALAKLDKN SFKEAISSTI SPQQKAIIGS VMEAYVKSQS 2001 LGSVEEAFQL KSFD*

Amino Acid Sequence (or in FASTA format)

       1  MANRSLKKVI ETSSNNGHDL LTWITTNLEK LICLKEVNDN EIQEVKEIHT
      51  QLDEFVRYIS VLENTDDLEL HSVFISLSQL YTISIWRLKD EYPGVVFDSA
     101  AFLTNVLCEE DVSIDDGDTD PNQKKKKKKS STKKKKYIYS PAKDIACTIL
     151  VQLFENFGSS ISSLIPLLFN AIFKNLKKIM EKSKYYHATF MTTLLQLFNA
     201  ILRNSNNDDK ILDPATYAKF SKLSKTVFDS ISTDEKDFSV TFVSVLIECW
     251  TAHFKQTNFI REHSHDIIET IYSRFTEGEI GVYGFANDET RIFTAKSLAE
     301  ILFDYYFSKN ILTLQEVWSI YVKIFLNCDT RDVESGCFES IIHLINLNLL
     351  ADNTFLSNSK YLDIVLSLSG VFSSYEVNNR SMNTLSRYLR YFQHMHEVIL
     401  PHLNDSAKTQ MLYYILGCSD TYQSSSKSDS ASNFKYSIDA KPETQWLTLL
     451  QLDFTYVLIS DLGSTFTTEE NTVKEIRDKL VDLATCEIFT IRVHTVEILK
     501  VFLNNCPEYL SETIENSLRA LSTDFKSTGK FIFHKNHGHA FIIANLIKGA
     551  ESDYISYELI MRITVFSTSF IKNNTTSTSS NLYFKGLLCW ILLIGLMNYK
     601  DEQYLKLQIP QLFLFWKVLL THTYTYHDED ELYKNLEIRN HALTCLLTYL
     651  SNTTIDKEMA KQVSYLLTKC SNFNHSIDLK SKNIDNALLH NENRILQVYL
     701  KLEKYINSDF NSSLLILIVK NFSDPNLYTE SSSSVLGSLK DIGNRKVSNK
     751  DDMESNIVLE SSINTLLRQN NGFAFGLSSK ITGDRIVNLS MSSAYKYDES
     801  ISGSWPSKDY NWYNIFEVEV SKPISPILSL DSLILLYGSG SYSQIDRYAP
     851  QVTTSLIDSS MELFSSVFPF LNSKIQYSIM ETLNLSMFSK MTTPLRSVAV
     901  AANVCSALHN ALRIMQENNL ELDYSVGQLI IESIKKIQFF NDIFLTKIKA
     951  DCVGLLTAAI ARTLGDEERQ KFLTEQSRIF IKNVADMDEP YLRMFHVLSL
    1001  ATIFKYNSQY ANFEEYFDVI FALMRDPHPV VHSWSLKAMH ILLEKHLVID
    1051  LKTAALLLSS MEELLVQDKY GIYGRSTLRC NYNRDFNSHV AIGEISRTLT
    1101  ETVGPNFLEL NTKVLDSFRN ITLSMLISNN ILNSITSIKM FENIATFKMK
    1151  NILNYEIFIL ASKSIIKSSI VTGIGSSYFD TTFTGSNELI SRTSSLKGAF
    1201  ENFDLLTLLY KLQMEEFFMK EMENLSWRYL ALFPNSGSVK NYFTEWILHT
    1251  FKRDNHWFDK LYSIFNMSLG RLFQSYNRDV SALLEVNGLK KSSEKEIKGE
    1301  EEESIANVNQ LTDTDAGGLD SENLQWKSRQ IILNLILMLC LESEKYENLL
    1351  LALSNKIADL IKISFRGSTV RNEGMKLTGL HILNFVLKNY STMRDPQVPG
    1401  SSILEQQEAQ ITSALMPAFS KGSSPTVMSF AITVAAEVLA SNIMPPDKLG
    1451  RISQLLIDLL GNFKDPNSGI RIGEAIIVTP KAKRKIELAV LDAWAEVVQR
    1501  SITSSNDALF SFTRKYWSIL VPLWIISLRE YMMIKYNDND STVQVKNDSK
    1551  ENSLIEPRST KIELYEPVWL NFVEALGCTL DSDVQVILAS LNDEELEYFL
    1601  FILFSQCLEA IVKNIDDHSV KMQVLPALHN VLKSNLCIKS IFEDDIITEV
    1651  VEIMDRLIST GDSKEEFLLV DIISDLIIGY SKCNATPETF LQDIDKLYEL
    1701  LRLLMTIISE RLPFIKYNVL TSEEDDNEIK ISPTDISLLK KTFIAFESNI
    1751  SNFDNMFKVD LYSCLLFIIG KIYECSHREV IIPIILPLFK ALVKALTESE
    1801  DEKNIVLLEI FYGSIKDVIY HKLDSKNKVA TILILLSNGY SKLSFQELNQ
    1851  CANILSEALN NPATQPIALQ GFKRIISNIF KYPLLQYFMK LVIKRFFQDI
    1901  QTNDSLSQAS IKTKLIIQFS EEVIKQDHQK ASLSIALCLS FFAAYHSAYT
    1951  EKIDNEVASG IVALAKLDKN SFKEAISSTI SPQQKAIIGS VMEAYVKSQS
    2001  LGSVEEAFQL KSFD*

external links for Laa1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Laa1p

1)	Fernandez GE and Payne GS (2006) Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast. Mol Biol Cell 17(7):3304-17
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41