ACO2/YJL200C Protein Information Help

Standard Name Aco2p 1
Systematic Name Yjl200cp
ORF Classification Verified
Description Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol (1, 2, 3, 4, 5)
Name Description ACOnitase
Experimental Data
Molecules/cell 4670 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 789
Molecular Weight (Da) 86,582
Isoelectric Point (pI) 6.94

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Aco2p (InterPro)
Physical Interactions There are 6 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001252E5 | P39533
MIPS: YJL200C
NCBI: 1008419 | 547592 | 6322261 | 728783 | NP_012335.1
GenBank/EMBL/DDBJ: DAA08609.1 | X77688 | Z49475
External Classifications EC: 4.2.1.3 [Aconitate hydratase]
Amino Acid Sequence (or in FASTA format)
 
       1  MLSSANRFYI KRHLATHANM FPSVSKNFQT KVPPYAKLLT NLDKIKQITN
      51  NAPLTLAEKI LYSHLCDPEE SITSSDLSTI RGNKYLKLNP DRVAMQDASA
     101  QMALLQFMTT GLNQTSVPAS IHCDHLIVGK DGETKDLPSS IATNQEVFDF
     151  LESCAKRYGI QFWGPGSGII HQIVLENFSA PGLMMLGTDS HTPNAGGLGA
     201  IAIGVGGADA VDALTGTPWE LKAPKILGVK LTGKLNGWST PKDVITKLAG
     251  LLTVRGGTGY IVEYFGEGVS TLSCTGMATI CNMGAEIGAT TSTFPYQEAH
     301  KRYLQATNRA EVAEAADVAL NKFNFLRADK DAQYDKVIEI DLSAIEPHVN
     351  GPFTPDLSTP ISQYAEKSLK ENWPQKVSAG LIGSCTNSSY QDMSRVVDLV
     401  KQASKAGLKP RIPFFVTPGS EQIRATLERD GIIDIFQENG AKVLANACGP
     451  CIGQWNREDV SKTSKETNTI FTSFNRNFRA RNDGNRNTMN FLTSPEIVTA
     501  MSYSGDAQFN PLTDSIKLPN GKDFKFQPPK GDELPKRGFE HGRDKFYPEM
     551  DPKPDSNVEI KVDPNSDRLQ LLEPFKPWNG KELKTNVLLK VEGKCTTDHI
     601  SAAGVWLKYK GHLENISYNT LIGAQNKETG EVNKAYDLDG TEYDIPGLMM
     651  KWKSDGRPWT VIAEHNYGEG SAREHAALSP RFLGGEILLV KSFARIHETN
     701  LKKQGVLPLT FANESDYDKI SSGDVLETLN LVDMIAKDGN NGGEIDVKIT
     751  KPNGESFTIK AKHTMSKDQI DFFKAGSAIN YIGNIRRNE*

external links for Aco2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Aco2p
1) van den Berg MA, et al.  (1998) Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism. Yeast 14(12):1089-104
2) Przybyla-Zawislak B, et al.  (1999) Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics 152(1):153-66
3) Natarajan K, et al.  (2001) Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol 21(13):4347-68
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41