CDC6/YJL194W Protein Information

Standard Name	Cdc6p 1
Systematic Name	Yjl194wp
ORF Classification	Verified
Description	Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress (2, 3)
Name Description	Cell Division Cycle 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	513
Molecular Weight (Da)	58,036
Isoelectric Point (pI)	10.23

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cdc6p (InterPro)
Physical Interactions	There are 75 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052ECD \| P09119 MIPS: YJL194W NCBI: 1008409 \| 171197 \| 171200 \| 171206 \| 3506 \| 3510 \| 547601 \| 6322266 \| 729078 \| NP_012341.1 GenBank/EMBL/DDBJ: DAA08613.1 \| J04734 \| M22858 \| M61183 \| X13118 \| X65299 \| X77688 \| Z49470

Amino Acid Sequence (or in FASTA format)
1 MSAIPITPTK RIRRNLFDDA PATPPRPLKR KKLQFTDVTP ESSPEKLQFG 51 SQSIFLRTKA LLQKSSELVN LNSSDGALPA RTAEYEQVMN FLAKAISEHR 101 SDSLYITGPP GTGKTAQLDM IIRQKFQSLP LSLSTPRSKD VLRHTNPNLQ 151 NLSWFELPDG RLESVAVTSI NCISLGEPSS IFQKIFDSFQ DLNGPTLQIK 201 NMQHLQKFLE PYHKKTTFVV VLDEMDRLLH ANTSETQSVR TILELFLLAK 251 LPTVSFVLIG MANSLDMKDR FLSRLNLDRG LLPQTIVFQP YTAEQMYEIV 301 IQKMSSLPTI IFQPMAIKFA AKKCAGNTGD LRKLFDVLRG SIEIYELEKR 351 FLLSPTRGSL NSAQVPLTPT TSPVKKSYPE PQGKIGLNYI AKVFSKFVNN 401 NSTRTRIAKL NIQQKLILCT IIQSLKLNSD ATIDESFDHY IKAITKTDTL 451 APLQRNEFLE ICTILETCGL VSIKKTKCKG KTKRFVDKID VDLDMREFYD 501 EMTKISILKP FLH*

Amino Acid Sequence (or in FASTA format)

       1  MSAIPITPTK RIRRNLFDDA PATPPRPLKR KKLQFTDVTP ESSPEKLQFG
      51  SQSIFLRTKA LLQKSSELVN LNSSDGALPA RTAEYEQVMN FLAKAISEHR
     101  SDSLYITGPP GTGKTAQLDM IIRQKFQSLP LSLSTPRSKD VLRHTNPNLQ
     151  NLSWFELPDG RLESVAVTSI NCISLGEPSS IFQKIFDSFQ DLNGPTLQIK
     201  NMQHLQKFLE PYHKKTTFVV VLDEMDRLLH ANTSETQSVR TILELFLLAK
     251  LPTVSFVLIG MANSLDMKDR FLSRLNLDRG LLPQTIVFQP YTAEQMYEIV
     301  IQKMSSLPTI IFQPMAIKFA AKKCAGNTGD LRKLFDVLRG SIEIYELEKR
     351  FLLSPTRGSL NSAQVPLTPT TSPVKKSYPE PQGKIGLNYI AKVFSKFVNN
     401  NSTRTRIAKL NIQQKLILCT IIQSLKLNSD ATIDESFDHY IKAITKTDTL
     451  APLQRNEFLE ICTILETCGL VSIKKTKCKG KTKRFVDKID VDLDMREFYD
     501  EMTKISILKP FLH*

external links for Cdc6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cdc6p

1)	Hilger, F. (1985) Personal Communication, Mortimer Map Edition 9
2)	Bell SP and Dutta A (2002) DNA replication in eukaryotic cells. Annu Rev Biochem 71():333-74
3)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4)	Hartwell LH, et al. (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9