ATG27/YJL178C Protein Information

Standard Name	Atg27p 1
Systematic Name	Yjl178cp
Alias	Etf1p 2
ORF Classification	Verified
Description	Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site (2, 3)
Name Description	AuTophaGy related 1

Experimental Data
Molecules/cell	8970 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	271
Molecular Weight (Da)	30,201
Isoelectric Point (pI)	5.53

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atg27p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 48 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000034F5CB \| P46989 MIPS: YJL178C NCBI: 1008378 \| 30267778 \| 42742253 \| 45270392 \| 61252455 \| NP_012357.2 GenBank/EMBL/DDBJ: DAA08627.1 \| AY260894 \| AY558251 \| Z49453

Amino Acid Sequence (or in FASTA format)
1 MVSKTWICGF ISIITVVQAL SCEKHDVLKK YQVGKFSSLT STERDTPPST 51 TIEKWWINVC EEHNVEPPEE CKKNDMLCGL TDVILPGKDA ITTQIIDFDK 101 NIGFNVEETE SALTLTLKGA TWGANSFDAK LEFQCNDNMK QDELTSHTWA 151 DKSIQLTLKG PSGCLKSKDD DKKNGDGDNG KDGDSEGKKP AKKAGGTSWF 201 TWLFLYALLF TLIYLMVVSF LNTRGGSFQD FRAEFIQRST QFLTSLPEFC 251 KEVVSRILGR STAQRGGYSA V*

Amino Acid Sequence (or in FASTA format)

       1  MVSKTWICGF ISIITVVQAL SCEKHDVLKK YQVGKFSSLT STERDTPPST
      51  TIEKWWINVC EEHNVEPPEE CKKNDMLCGL TDVILPGKDA ITTQIIDFDK
     101  NIGFNVEETE SALTLTLKGA TWGANSFDAK LEFQCNDNMK QDELTSHTWA
     151  DKSIQLTLKG PSGCLKSKDD DKKNGDGDNG KDGDSEGKKP AKKAGGTSWF
     201  TWLFLYALLF TLIYLMVVSF LNTRGGSFQD FRAEFIQRST QFLTSLPEFC
     251  KEVVSRILGR STAQRGGYSA V*

external links for Atg27p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Atg27p

1)	Klionsky DJ, et al. (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
2)	Wurmser AE and Emr SD (2002) Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy. J Cell Biol 158(4):761-72
3)	Yen WL, et al. (2007) Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell 18(2):581-93
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41