HAL5/YJL165C Protein Information Help

Standard Name Hal5p
Systematic Name Yjl165cp
ORF Classification Verified
Description Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication (1, 2)
Name Description HALotolerance 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 855
Molecular Weight (Da) 95,454
Isoelectric Point (pI) 8.43

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hal5p (InterPro)
Physical Interactions There are 39 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012C058 | P38970
MIPS: YJL165C
NCBI: 1008354 | 1170165 | 557484 | 6322296 | NP_012370.1
GenBank/EMBL/DDBJ: DAA08638.1 | U15300 | Z49440
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MGDEKLSRHT SLKRARSLSE SIKGLFKPSG ISGSNNAAAP SSRPGQDQAH
      51  SHQTARIITS NVSSPSISPV HSPVLQAAPK HHKLGVPNIA KLSLSPSREP
     101  SLNSENEMFS QESFISEKDE DEANLLERED LQNKKEEKAR AKHVRSKEAY
     151  VPHHRYTVGS DEVERQPRER LKNFPQNAGS SNPANSNANH VLDQENNFSI
     201  DAMLDYDEES KLRRRNSLGV RNHSNRTRSR KNSLSTPRSP PMKNGNGGMN
     251  SNATNNVGNG TGNRIYMRGR NHSDSISASS LPKFQEIECK CILDLGHFKV
     301  FENGYHEHSL RVLPIITNNK NVDSGDEKDA DASVNSGDDG DNDSEANMHK
     351  QKSVFSLSGL FKSHKDGNQQ QQQQQQQEEN GEQINLEKAF SIIPSQRFIK
     401  SQTLKKSRTS NLKNGNNDEL MKNDGKNIPQ IVNPNAAVGV EELKLINALS
     451  EKIRKGLKSE NTKGNNGEGR SNSNKQEDSD DTEGKAGTTN DDTSHKPCSQ
     501  KYGKSIGVVG AGAYGVVKIC ARCKTAKDVL PYSTYSNGKK LFFAVKELKP
     551  KPGDQIDKFC TRLTSEFIIG HSLSHPHFEA NAMIAGNVSR TTPPKHVFNA
     601  PNILKILDLM EYSNSFVEVM EFCASGDLYS LLTRNNISNE SNNGSSRLIQ
     651  TVKEGSGSPL HPLEADCFMK QLLNGVQYMH DHGIAHCDLK PENILFQPNG
     701  LLKICDFGTS SVFQTAWEKH VHFQSGAMGS EPYVAPEEFI RDAEYDPRLV
     751  DCWSCGIVYC TMVMGQYLWK IAIPEKDSLF KSFLSEIKDD GQFYLFEELR
     801  HVSSELNRLR KIALYRTFQV DPTKRITIEQ LLQSSWMRKT KCCVVYRHLH
     851  TKVSK*

external links for Hal5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Hal5p
1) Mulet JM, et al.  (1999) A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter. Mol Cell Biol 19(5):3328-37
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61