INO1/YJL153C Protein Information

Standard Name	Ino1p 1
Systematic Name	Yjl153cp
Alias	Apr1p
ORF Classification	Verified
Description	Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element (2, 3)
Name Description	INOsitol requiring 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	533
Molecular Weight (Da)	59,642
Isoelectric Point (pI)	5.77

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ino1p (InterPro)
Physical Interactions	There are 23 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000111F94 \| P11986 MIPS: YJL153C NCBI: 1015571 \| 170948 \| 20663912 \| 20663913 \| 20663916 \| 20663917 \| 20664334 \| 20664335 \| 20664336 \| 20664337 \| 33357825 \| 33357826 \| 33357827 \| 33357828 \| 33357829 \| 33357830 \| 33357831 \| 33357832 \| 33357833 \| 33357834 \| 33357835 \| 33357836 \| 37362665 \| 413760 \| 49258762 \| 49258763 \| 83303932 \| 854544 \| NP_012382.2 \| NM_001181586.1 GenBank/EMBL/DDBJ: DAA08650.1 \| J04453 \| L23520 \| X87371 \| Z49428
External Classifications	EC: 5.5.1.4 [Inositol-3-phosphate synthase]

Amino Acid Sequence (or in FASTA format)
1 MTEDNIAPIT SVKVVTDKCT YKDNELLTKY SYENAVVTKT ASGRFDVTPT 51 VQDYVFKLDL KKPEKLGIML IGLGGNNGST LVASVLANKH NVEFQTKEGV 101 KQPNYFGSMT QCSTLKLGID AEGNDVYAPF NSLLPMVSPN DFVVSGWDIN 151 NADLYEAMQR SQVLEYDLQQ RLKAKMSLVK PLPSIYYPDF IAANQDERAN 201 NCINLDEKGN VTTRGKWTHL QRIRRDIQNF KEENALDKVI VLWTANTERY 251 VEVSPGVNDT MENLLQSIKN DHEEIAPSTI FAAASILEGV PYINGSPQNT 301 FVPGLVQLAE HEGTFIAGDD LKSGQTKLKS VLAQFLVDAG IKPVSIASYN 351 HLGNNDGYNL SAPKQFRSKE ISKSSVIDDI IASNDILYND KLGKKVDHCI 401 VIKYMKPVGD SKVAMDEYYS ELMLGGHNRI SIHNVCEDSL LATPLIIDLL 451 VMTEFCTRVS YKKVDPVKED AGKFENFYPV LTFLSYWLKA PLTRPGFHPV 501 NGLNKQRTAL ENFLRLLIGL PSQNELRFEE RLL*

Amino Acid Sequence (or in FASTA format)

       1  MTEDNIAPIT SVKVVTDKCT YKDNELLTKY SYENAVVTKT ASGRFDVTPT
      51  VQDYVFKLDL KKPEKLGIML IGLGGNNGST LVASVLANKH NVEFQTKEGV
     101  KQPNYFGSMT QCSTLKLGID AEGNDVYAPF NSLLPMVSPN DFVVSGWDIN
     151  NADLYEAMQR SQVLEYDLQQ RLKAKMSLVK PLPSIYYPDF IAANQDERAN
     201  NCINLDEKGN VTTRGKWTHL QRIRRDIQNF KEENALDKVI VLWTANTERY
     251  VEVSPGVNDT MENLLQSIKN DHEEIAPSTI FAAASILEGV PYINGSPQNT
     301  FVPGLVQLAE HEGTFIAGDD LKSGQTKLKS VLAQFLVDAG IKPVSIASYN
     351  HLGNNDGYNL SAPKQFRSKE ISKSSVIDDI IASNDILYND KLGKKVDHCI
     401  VIKYMKPVGD SKVAMDEYYS ELMLGGHNRI SIHNVCEDSL LATPLIIDLL
     451  VMTEFCTRVS YKKVDPVKED AGKFENFYPV LTFLSYWLKA PLTRPGFHPV
     501  NGLNKQRTAL ENFLRLLIGL PSQNELRFEE RLL*

external links for Ino1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ino1p

1)	Culbertson MR and Henry SA (1975) Inositol-requiring mutants of Saccharomyces cerevisiae. Genetics 80(1):23-40
2)	Ambroziak J and Henry SA (1994) INO2 and INO4 gene products, positive regulators of phospholipid biosynthesis in Saccharomyces cerevisiae, form a complex that binds to the INO1 promoter. J Biol Chem 269(21):15344-9
3)	Donahue TF and Henry SA (1981) myo-Inositol-1-phosphate synthase. Characteristics of the enzyme and identification of its structural gene in yeast. J Biol Chem 256(13):7077-85