YUR1/YJL139C Protein Information

Standard Name	Yur1p
Systematic Name	Yjl139cp
ORF Classification	Verified
Description	Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication (1, 2, 3, 4)

Experimental Data
Molecules/cell	6400 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	428
Molecular Weight (Da)	50,836
Isoelectric Point (pI)	5.01

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Yur1p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013C193 \| P26725 MIPS: YJL139C NCBI: 1015546 \| 141480 \| 4833 \| 6322322 \| 854558 \| NP_012396.1 GenBank/EMBL/DDBJ: DAA08661.1 \| X58099 \| X87371 \| Z49414
External Classifications	EC: 2.4.1.- [Hexosyltransferases] EC: 2.4.1.131 [GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MAKGGSLYIV GIFLPIWTFM IYIFGKELFL IRKYQKIDST YTALSQRVKE 51 QYDTSRRRNY FPKVKLSRNS YDDYTLNYTR QNDSDSFHLR ENATILMLVR 101 NSELEGALDS MRSLEDRFNN KYHYDWTFLN DVPFDQDFIE ATTSMASGKT 151 QYALIPPEDW NRPQWINDTL FEERLRVMED EGVLYGGSKS YRNMCRFNSG 201 FFFRQSILDN YDYYFRVEPN VKYYCDFPYD PFRVMRLKGK KYGFVISLYE 251 YEETIPTLWD AVEEYLVASE ETILRKEDSA YAFLTDSGLV GKHYPVVEAN 301 SDYNLCHFWS NFEIGDLNFF RSDEYKHFFE TLDAKGGFYY ERWGDAPVHS 351 IGVSLLLRPD EIIHFDELGY FHSPFGTCPA SYAVRLDQRC RCKSDDESVI 401 DITPHSCLMR WWKNGSGKYF LKEEQDEI*

Amino Acid Sequence (or in FASTA format)

       1  MAKGGSLYIV GIFLPIWTFM IYIFGKELFL IRKYQKIDST YTALSQRVKE
      51  QYDTSRRRNY FPKVKLSRNS YDDYTLNYTR QNDSDSFHLR ENATILMLVR
     101  NSELEGALDS MRSLEDRFNN KYHYDWTFLN DVPFDQDFIE ATTSMASGKT
     151  QYALIPPEDW NRPQWINDTL FEERLRVMED EGVLYGGSKS YRNMCRFNSG
     201  FFFRQSILDN YDYYFRVEPN VKYYCDFPYD PFRVMRLKGK KYGFVISLYE
     251  YEETIPTLWD AVEEYLVASE ETILRKEDSA YAFLTDSGLV GKHYPVVEAN
     301  SDYNLCHFWS NFEIGDLNFF RSDEYKHFFE TLDAKGGFYY ERWGDAPVHS
     351  IGVSLLLRPD EIIHFDELGY FHSPFGTCPA SYAVRLDQRC RCKSDDESVI
     401  DITPHSCLMR WWKNGSGKYF LKEEQDEI*

external links for Yur1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Yur1p

1)	Lussier M, et al. (1996) Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. J Biol Chem 271(18):11001-8
2)	Hill K, et al. (1992) Yeast KRE2 defines a new gene family encoding probable secretory proteins, and is required for the correct N-glycosylation of proteins. Genetics 130(2):273-83
3)	Lussier M, et al. (1999) The KTR and MNN1 mannosyltransferase families of Saccharomyces cerevisiae. Biochim Biophys Acta 1426(2):323-34
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41