TRK1/YJL129C Protein Information

Standard Name	Trk1p 1
Systematic Name	Yjl129cp
ORF Classification	Verified
Description	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	TRansport of potassium (K)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,235
Molecular Weight (Da)	141,072
Isoelectric Point (pI)	8.87

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Trk1p (InterPro)
Transmembrane Domains	There are 8 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001373BD \| P12685 MIPS: YJL129C NCBI: 1008330 \| 136231 \| 171804 \| 6322332 \| NP_012406.1 GenBank/EMBL/DDBJ: DAA08672.1 \| M21328 \| Z49404
External Classifications	TC: 2.A.38.2

Amino Acid Sequence (or in FASTA format)
1 MHFRRTMSRV PTLASLEIRY KKSFGHKFRD FIALCGHYFA PVKKYIFPSF 51 IAVHYFYTIS LTLITSILLY PIKNTRYIDT LFLAAGAVTQ GGLNTVDINN 101 LSLYQQIVLY IVCCISTPIA VHSCLAFVRL YWFERYFDGI RDSSRRNFKM 151 RRTKTILERE LTARTMTKNR TGTQRTSYPR KQAKTDDFQE KLFSGEMVNR 201 DEQDSVHSDQ NSHDISRDSS NNNTNHNGSS GSLDDFVKED ETDDNGEYQE 251 NNSYSTVGSS SNTVADESLN QKPKPSSLRF DEPHSKQRPA RVPSEKFAKR 301 RGSRDISPAD MYRSIMMLQG KHEATAEDEG PPLVIGSPAD GTRYKSNVNK 351 LKKATGINGN KIKIRDKGNE SNTDQNSVSS EANSTASVSD ESSLHTNFGN 401 KVPSLRTNTH RSNSGPIAIT DNAETDKKHG PSIQFDITKP PRKISKRVST 451 FDDLNPKSSV LYRKKASKKY LMKHFPKARR IRQQIKRRLS TGSIEKNSSN 501 NVSDRKPITD MDDDDDDDDN DGDNNEEYFA DNESGDEDER VQQSEPHSDS 551 ELKSHQQQQE KHQLQQNLHR MYKTKSFDDN RSRAVPMERS RTIDMAEAKD 601 LNELARTPDF QKMVYQNWKA HHRKKPNFRK RGWNNKIFEH GPYASDSDRN 651 YPDNSNTGNS ILHYAESILH HDGSHKNGSE EASSDSNENI YSTNGGSDHN 701 GLNNYPTYND DEEGYYGLHF DTDYDLDPRH DLSKGSGKTY LSWQPTIGRN 751 SNFLGLTRAQ KDELGGVEYR AIKLLCTILV VYYVGWHIVA FVMLVPWIIL 801 KKHYSEVVRD DGVSPTWWGF WTAMSAFNDL GLTLTPNSMM SFNKAVYPLI 851 VMIWFIIIGN TGFPILLRCI IWIMFKISPD LSQMRESLGF LLDHPRRCFT 901 LLFPKAATWW LLLTLAGLNI TDWILFIILD FGSTVVKSLS KGYRVLVGLF 951 QSVSTRTAGF SVVDLSQLHP SIQVSYMLMM YVSVLPLAIS IRRTNVYEEQ 1001 SLGLYGDMGG EPEDTDTEDD GNDEDDDEEN ESHEGQSSQR SSSNNNNNNN 1051 RKKKKKKKTE NPNEISTKSF IGAHLRKQLS FDLWFLFLGL FIICICEGDK 1101 IKDVQEPNFN IFAILFEIVS AYGTVGLSLG YPDTNQSFSR QFTTLSKLVI 1151 IAMLIRGKNR GLPYSLDRAI ILPSDRLEHI DHLEGMKLKR QARTNTEDPM 1201 TEHFKRSFTD VKHRWGALKR KTTHSRNPKR SSTTL*

Amino Acid Sequence (or in FASTA format)

       1  MHFRRTMSRV PTLASLEIRY KKSFGHKFRD FIALCGHYFA PVKKYIFPSF
      51  IAVHYFYTIS LTLITSILLY PIKNTRYIDT LFLAAGAVTQ GGLNTVDINN
     101  LSLYQQIVLY IVCCISTPIA VHSCLAFVRL YWFERYFDGI RDSSRRNFKM
     151  RRTKTILERE LTARTMTKNR TGTQRTSYPR KQAKTDDFQE KLFSGEMVNR
     201  DEQDSVHSDQ NSHDISRDSS NNNTNHNGSS GSLDDFVKED ETDDNGEYQE
     251  NNSYSTVGSS SNTVADESLN QKPKPSSLRF DEPHSKQRPA RVPSEKFAKR
     301  RGSRDISPAD MYRSIMMLQG KHEATAEDEG PPLVIGSPAD GTRYKSNVNK
     351  LKKATGINGN KIKIRDKGNE SNTDQNSVSS EANSTASVSD ESSLHTNFGN
     401  KVPSLRTNTH RSNSGPIAIT DNAETDKKHG PSIQFDITKP PRKISKRVST
     451  FDDLNPKSSV LYRKKASKKY LMKHFPKARR IRQQIKRRLS TGSIEKNSSN
     501  NVSDRKPITD MDDDDDDDDN DGDNNEEYFA DNESGDEDER VQQSEPHSDS
     551  ELKSHQQQQE KHQLQQNLHR MYKTKSFDDN RSRAVPMERS RTIDMAEAKD
     601  LNELARTPDF QKMVYQNWKA HHRKKPNFRK RGWNNKIFEH GPYASDSDRN
     651  YPDNSNTGNS ILHYAESILH HDGSHKNGSE EASSDSNENI YSTNGGSDHN
     701  GLNNYPTYND DEEGYYGLHF DTDYDLDPRH DLSKGSGKTY LSWQPTIGRN
     751  SNFLGLTRAQ KDELGGVEYR AIKLLCTILV VYYVGWHIVA FVMLVPWIIL
     801  KKHYSEVVRD DGVSPTWWGF WTAMSAFNDL GLTLTPNSMM SFNKAVYPLI
     851  VMIWFIIIGN TGFPILLRCI IWIMFKISPD LSQMRESLGF LLDHPRRCFT
     901  LLFPKAATWW LLLTLAGLNI TDWILFIILD FGSTVVKSLS KGYRVLVGLF
     951  QSVSTRTAGF SVVDLSQLHP SIQVSYMLMM YVSVLPLAIS IRRTNVYEEQ
    1001  SLGLYGDMGG EPEDTDTEDD GNDEDDDEEN ESHEGQSSQR SSSNNNNNNN
    1051  RKKKKKKKTE NPNEISTKSF IGAHLRKQLS FDLWFLFLGL FIICICEGDK
    1101  IKDVQEPNFN IFAILFEIVS AYGTVGLSLG YPDTNQSFSR QFTTLSKLVI
    1151  IAMLIRGKNR GLPYSLDRAI ILPSDRLEHI DHLEGMKLKR QARTNTEDPM
    1201  TEHFKRSFTD VKHRWGALKR KTTHSRNPKR SSTTL*

external links for Trk1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Trk1p

1)	Gaber RF, et al. (1988) TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae. Mol Cell Biol 8(7):2848-59
2)	Ko CH and Gaber RF (1991) TRK1 and TRK2 encode structurally related K+ transporters in Saccharomyces cerevisiae. Mol Cell Biol 11(8):4266-73
3)	Yenush L, et al. (2005) pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase. Mol Cell Biol 25(19):8683-92
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61