MDV1/YJL112W Protein Information Help

Standard Name Mdv1p 1
Systematic Name Yjl112wp
Alias Fis2p 2 , Gag3p , Net2p
ORF Classification Verified
Description Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description Mitochondrial DiVision 1
Experimental Data
Molecules/cell 3730 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 714
Molecular Weight (Da) 80,031
Isoelectric Point (pI) 5.32

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mdv1p (InterPro)
Physical Interactions There are 76 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B5E4 | P47025
MIPS: YJL112W
NCBI: 1008299 | 1353001 | 160285785 | 310689677 | 310689678 | 374977774 | 374977776 | 6322349 | NP_012423.1 | NM_001181545.2
GenBank/EMBL/DDBJ: DAA08688.1 | Z49387
Amino Acid Sequence (or in FASTA format)
 
       1  MSVNDQITHI GKTLSTTASA FLNYQKSNSN TQDVLTNNGP YKNLLSNTVN
      51  NASSTSYFYK RTEHGRFVKN ASNTFEDIYS KTRRGDVFRN KFTDNKTCFR
     101  MLTYISDDLL NEIPTKEGLK SDADGKLLTE GGENENLRKN ASKKETSLFQ
     151  GFKSYLPIAE LAIENTERLN YDTNGTSGTV GAKDVMSKTN ERDEIHTELP
     201  NFQDSFLIPP GVETKKISSS YSPSALKSFS QTLVNSLEFL NIQKNSTLSE
     251  IRDIEVEVEN LRQKKEKLLG KIANIEQNQL LLEDNLKQID DRLDFLEEYG
     301  LEVIEANSDE NAEDDGMSER KALKNDAIRN EGVTTESISS EASNLPPRRR
     351  QQLRDDNSLN RLGAFYSKSK KRHRKSFPTF QQLYEPGTKI GSIMSTHDDF
     401  LTCLDFDAPF GTLCTAGYLD HTVKIWDLSK QNKIGELAGH LATINCMQIN
     451  RDYGTLVTGG RDAALKLWNL NLAQQLYQET QNLTSPTNHI DSPCVHTFEA
     501  HTDEVTALSL DPSFLVSGSQ DRTIRQWDLR SGKCLQTIDL SFANVLTTST
     551  NVDLSKSTLL TQRNERPSIG ALQSFDAALA TGTKDGVVRL WDLRSGKVIR
     601  TLKGHTDAIT SLKFDSACLV TGSYDRTVRI WDLRTGLLNK FHAYSAPVLS
     651  LDLFQENAAV VVADEPSVQI YDSEKDESWS CVEQGNETSV STVKYKENYM
     701  VEGRENGDVN IWAV*

external links for Mdv1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
YGOB CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Mdv1p
1) Tieu Q and Nunnari J  (2000) Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J Cell Biol 151(2):353-66
2) Mozdy AD, et al.  (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80
3) Fekkes P, et al.  (2000) Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol 151(2):333-40
4) Cerveny KL and Jensen RE  (2003) The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria. Mol Biol Cell 14(10):4126-39
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41