UTP10/YJL109C Protein Information

Standard Name	Utp10p 1
Systematic Name	Yjl109cp
ORF Classification	Verified
Description	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance (1, 2)
Name Description	U Three Protein 1

Experimental Data
Molecules/cell	18200 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,769
Molecular Weight (Da)	200,079
Isoelectric Point (pI)	6.45

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Utp10p (InterPro)
Physical Interactions	There are 221 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F40 \| P42945 MIPS: YJL109C NCBI: 1008293 \| 1176489 \| 6322352 \| 728701 \| NP_012426.1 GenBank/EMBL/DDBJ: DAA08691.1 \| X85021 \| Z49384

Amino Acid Sequence (or in FASTA format)
1 MSSLSDQLAQ VASNNATVAL DRKRRQKLHS ASLIYNSKTA ATQDYDFIFE 51 NASKALEELS QIEPKFAIFS RTLFSESSIS LDRNVQTKEE IKDLDNAINA 101 YLLLASSKWY LAPTLHATEW LVRRFQIHVK NTEMLLLSTL NYYQTPVFKR 151 ILSIIKLPPL FNCLSNFVRS EKPPTALTMI KLFNDMDFLK LYTSYLDQCI 201 KHNATYTNQL LFTTCCFINV VAFNSNNDEK LNQLVPILLE ISAKLLASKS 251 KDCQIAAHTI LVVFATALPL KKTIILAAME TILSNLDAKE AKHSALLTIC 301 KLFQTLKGQG NVDQLPSKIF KLFDSKFDTV SILTFLDKED KPVCDKFITS 351 YTRSIARYDR SKLNIILSLL KKIRLERYEV RLIITDLIYL SEILEDKSQL 401 VELFEYFISI NEDLVLKCLK SLGLTGELFE IRLTTSLFTN ADVNTDIVKQ 451 LSDPVETTKK DTASFQTFLD KHSELINTTN VSMLTETGER YKKVLSLFTE 501 AIGKGYKASS FLTSFFTTLE SRITFLLRVT ISPAAPTALK LISLNNIAKY 551 INSIEKEVNI FTLVPCLICA LRDASIKVRT GVKKILSLIA KRPSTKHYFL 601 SDKLYGENVT IPMLNPKDSE AWLSGFLNEY VTENYDISRI LTPKRNEKVF 651 LMFWANQALL IPSPYAKTVL LDNLNKSPTY ASSYSSLFEE FISHYLENRS 701 SWEKSCIANK TNFEHFERSL VNLVSPKEKQ SFMIDFVLSA LNSDYEQLAN 751 IAAERLISIF ASLNNAQKLK IVQNIVDSSS NVESSYDTVG VLQSLPLDSD 801 IFVSILNQNS ISNEMDQTDF SKRRRRRSST SKNAFLKEEV SQLAELHLRK 851 LTIILEALDK VRNVGSEKLL FTLLSLLSDL ETLDQDGGLP VLYAQETLIS 901 CTLNTITYLK EHGCTELTNV RADILVSAIR NSASPQVQNK LLLVIGSLAT 951 LSSEVILHSV MPIFTFMGAH SIRQDDEFTT KVVERTILTV VPALIKNSKG 1001 NEKEEMEFLL LSFTTALQHV PRHRRVKLFS TLIKTLDPVK ALGSFLFLIA 1051 QQYSSALVNF KIGEARILIE FIKALLVDLH VNEELSGLND LLDIIKLLTS 1101 SKSSSEKKKS LESRVLFSNG VLNFSESEFL TFMNNTFEFI NKITEETDQD 1151 YYDVRRNLRL KVYSVLLDET SDKKLIRNIR EEFGTLLEGV LFFINSVELT 1201 FSCITSQENE EASDSETSLS DHTTEIKEIL FKVLGNVLQI LPVDEFVNAV 1251 LPLLSTSTNE DIRYHLTLVI GSKFELEGSE AIPIVNNVMK VLLDRMPLES 1301 KSVVISQVIL NTMTALVSKY GKKLEGSILT QALTLATEKV SSDMTEVKIS 1351 SLALITNCVQ VLGVKSIAFY PKIVPPSIKL FDASLADSSN PLKEQLQVAI 1401 LLLFAGLIKR IPSFLMSNIL DVLHVIYFSR EVDSSIRLSV ISLIIENIDL 1451 KEVLKVLFRI WSTEIATSND TVAVSLFLST LESTVENIDK KSATSQSPIF 1501 FKLLLSLFEF RSISSFDNNT ISRIEASVHE ISNSYVLKMN DKVFRPLFVI 1551 LVRWAFDGEG VTNAGITETE RLLAFFKFFN KLQENLRGII TSYFTYLLEP 1601 VDMLLKRFIS KDMENVNLRR LVINSLTSSL KFDRDEYWKS TSRFELISVS 1651 LVNQLSNIEN SIGKYLVKAI GALASNNSGV DEHNQILNKL IVEHMKASCS 1701 SNEKLWAIRA MKLIYSKIGE SWLVLLPQLV PVIAELLEDD DEEIEREVRT 1751 GLVKVVENVL GEPFDRYLD*

Amino Acid Sequence (or in FASTA format)

       1  MSSLSDQLAQ VASNNATVAL DRKRRQKLHS ASLIYNSKTA ATQDYDFIFE
      51  NASKALEELS QIEPKFAIFS RTLFSESSIS LDRNVQTKEE IKDLDNAINA
     101  YLLLASSKWY LAPTLHATEW LVRRFQIHVK NTEMLLLSTL NYYQTPVFKR
     151  ILSIIKLPPL FNCLSNFVRS EKPPTALTMI KLFNDMDFLK LYTSYLDQCI
     201  KHNATYTNQL LFTTCCFINV VAFNSNNDEK LNQLVPILLE ISAKLLASKS
     251  KDCQIAAHTI LVVFATALPL KKTIILAAME TILSNLDAKE AKHSALLTIC
     301  KLFQTLKGQG NVDQLPSKIF KLFDSKFDTV SILTFLDKED KPVCDKFITS
     351  YTRSIARYDR SKLNIILSLL KKIRLERYEV RLIITDLIYL SEILEDKSQL
     401  VELFEYFISI NEDLVLKCLK SLGLTGELFE IRLTTSLFTN ADVNTDIVKQ
     451  LSDPVETTKK DTASFQTFLD KHSELINTTN VSMLTETGER YKKVLSLFTE
     501  AIGKGYKASS FLTSFFTTLE SRITFLLRVT ISPAAPTALK LISLNNIAKY
     551  INSIEKEVNI FTLVPCLICA LRDASIKVRT GVKKILSLIA KRPSTKHYFL
     601  SDKLYGENVT IPMLNPKDSE AWLSGFLNEY VTENYDISRI LTPKRNEKVF
     651  LMFWANQALL IPSPYAKTVL LDNLNKSPTY ASSYSSLFEE FISHYLENRS
     701  SWEKSCIANK TNFEHFERSL VNLVSPKEKQ SFMIDFVLSA LNSDYEQLAN
     751  IAAERLISIF ASLNNAQKLK IVQNIVDSSS NVESSYDTVG VLQSLPLDSD
     801  IFVSILNQNS ISNEMDQTDF SKRRRRRSST SKNAFLKEEV SQLAELHLRK
     851  LTIILEALDK VRNVGSEKLL FTLLSLLSDL ETLDQDGGLP VLYAQETLIS
     901  CTLNTITYLK EHGCTELTNV RADILVSAIR NSASPQVQNK LLLVIGSLAT
     951  LSSEVILHSV MPIFTFMGAH SIRQDDEFTT KVVERTILTV VPALIKNSKG
    1001  NEKEEMEFLL LSFTTALQHV PRHRRVKLFS TLIKTLDPVK ALGSFLFLIA
    1051  QQYSSALVNF KIGEARILIE FIKALLVDLH VNEELSGLND LLDIIKLLTS
    1101  SKSSSEKKKS LESRVLFSNG VLNFSESEFL TFMNNTFEFI NKITEETDQD
    1151  YYDVRRNLRL KVYSVLLDET SDKKLIRNIR EEFGTLLEGV LFFINSVELT
    1201  FSCITSQENE EASDSETSLS DHTTEIKEIL FKVLGNVLQI LPVDEFVNAV
    1251  LPLLSTSTNE DIRYHLTLVI GSKFELEGSE AIPIVNNVMK VLLDRMPLES
    1301  KSVVISQVIL NTMTALVSKY GKKLEGSILT QALTLATEKV SSDMTEVKIS
    1351  SLALITNCVQ VLGVKSIAFY PKIVPPSIKL FDASLADSSN PLKEQLQVAI
    1401  LLLFAGLIKR IPSFLMSNIL DVLHVIYFSR EVDSSIRLSV ISLIIENIDL
    1451  KEVLKVLFRI WSTEIATSND TVAVSLFLST LESTVENIDK KSATSQSPIF
    1501  FKLLLSLFEF RSISSFDNNT ISRIEASVHE ISNSYVLKMN DKVFRPLFVI
    1551  LVRWAFDGEG VTNAGITETE RLLAFFKFFN KLQENLRGII TSYFTYLLEP
    1601  VDMLLKRFIS KDMENVNLRR LVINSLTSSL KFDRDEYWKS TSRFELISVS
    1651  LVNQLSNIEN SIGKYLVKAI GALASNNSGV DEHNQILNKL IVEHMKASCS
    1701  SNEKLWAIRA MKLIYSKIGE SWLVLLPQLV PVIAELLEDD DEEIEREVRT
    1751  GLVKVVENVL GEPFDRYLD*

external links for Utp10p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Utp10p

1)	Dragon F, et al. (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417(6892):967-70
2)	Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41