IME2/YJL106W Protein Information

Standard Name	Ime2p
Systematic Name	Yjl106wp
Alias	Sme1p
ORF Classification	Verified
Description	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p (1, 2)
Name Description	Inducer of MEiosis 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	645
Molecular Weight (Da)	73,592
Isoelectric Point (pI)	5.13

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ime2p (InterPro)
Physical Interactions	There are 93 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012D61B \| P32581 MIPS: YJL106W NCBI: 1008288 \| 417780 \| 4496 \| 6322355 \| 728704 \| NP_012429.1 GenBank/EMBL/DDBJ: DAA08694.1 \| X53262 \| X85021 \| Z49381
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MVEKRSRQSS SSGSEFSVPP DVDNPPLSIP LKTLSDRYQL IEKLGAGSFG 51 CVTLAKAQFP LSNILGKQHD IRGTLMDQPK NGHQNYITKT QGVVAIKTMM 101 TKLHTLQDYT RVREIKFILA IPANDHLIQI FEVFIDSENY QLHIVMECME 151 QNLYQMMKHR RRRVFSIPSL KSILSQILAG LKHIHEHNFF HRDLKPENIL 201 ITPSTQYFEK EYMNQIGYQD NYVIKLADFG LARHVENKNP YTAYVSTRWY 251 RSPEILLRSG YYSKPLDIWA FGCVAVEVTV FRALFPGANE IDQIWKILEV 301 LGTPIKRSDF VNTNHITAPP PGGFWDDASN LVHKLNLKLP YVEGSSLDHL 351 LSSSQLSDLS EVVKKCLRWD PNERATAQEL CEMPFFENTV ASQVDARGNV 401 TNTEQALIFA GINPVATNTK PIYFNSSTKL PAETESNDID ISNNDHDSHA 451 MCSPTLNQEK LTLVEFLNEF VEEDNDDHSI PDVGTDSTIS DSIDETELSK 501 EIRNNLALCQ LPDEEVLDHS LSNIRQLTND IEIINKDEAD NMEQLFFDLE 551 IPEKDEFQRK QPFNEHADID EDIVLPYVNN SNYTHTDRSH HRGDNVLGDA 601 SLGDSFNSMP DFTPRNFLIP TLKKSREKFE PHLSNSNQHF GNVTF*

Amino Acid Sequence (or in FASTA format)

       1  MVEKRSRQSS SSGSEFSVPP DVDNPPLSIP LKTLSDRYQL IEKLGAGSFG
      51  CVTLAKAQFP LSNILGKQHD IRGTLMDQPK NGHQNYITKT QGVVAIKTMM
     101  TKLHTLQDYT RVREIKFILA IPANDHLIQI FEVFIDSENY QLHIVMECME
     151  QNLYQMMKHR RRRVFSIPSL KSILSQILAG LKHIHEHNFF HRDLKPENIL
     201  ITPSTQYFEK EYMNQIGYQD NYVIKLADFG LARHVENKNP YTAYVSTRWY
     251  RSPEILLRSG YYSKPLDIWA FGCVAVEVTV FRALFPGANE IDQIWKILEV
     301  LGTPIKRSDF VNTNHITAPP PGGFWDDASN LVHKLNLKLP YVEGSSLDHL
     351  LSSSQLSDLS EVVKKCLRWD PNERATAQEL CEMPFFENTV ASQVDARGNV
     401  TNTEQALIFA GINPVATNTK PIYFNSSTKL PAETESNDID ISNNDHDSHA
     451  MCSPTLNQEK LTLVEFLNEF VEEDNDDHSI PDVGTDSTIS DSIDETELSK
     501  EIRNNLALCQ LPDEEVLDHS LSNIRQLTND IEIINKDEAD NMEQLFFDLE
     551  IPEKDEFQRK QPFNEHADID EDIVLPYVNN SNYTHTDRSH HRGDNVLGDA
     601  SLGDSFNSMP DFTPRNFLIP TLKKSREKFE PHLSNSNQHF GNVTF*

external links for Ime2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ime2p

1)	Guttmann-Raviv N, et al. (2002) Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1. Mol Cell Biol 22(7):2047-56
2)	Sopko R, et al. (2002) Phosphorylation and maximal activity of Saccharomyces cerevisiae meiosis-specific transcription factor Ndt80 is dependent on Ime2. Mol Cell Biol 22(20):7024-40
3)	Kassir Y, et al. (1988) IME1, a positive regulator gene of meiosis in S. cerevisiae. Cell 52(6):853-62