SIP4/YJL089W Protein Information Help

Standard Name Sip4p 1, 2
Systematic Name Yjl089wp
ORF Classification Verified
Description C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus (1, 3, 4)
Name Description SNF1-Interacting Protein 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 829
Molecular Weight (Da) 96,004
Isoelectric Point (pI) 6.51

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sip4p (InterPro)
Physical Interactions There are 20 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001359A4 | P46954
MIPS: YJL089W
NCBI: 1008258 | 1173439 | 596255 | 6322372 | 929865 | NP_012446.1 | NM_001181522.1
GenBank/EMBL/DDBJ: DAA08711.1 | U17643 | X83502 | Z49364
Amino Acid Sequence (or in FASTA format)
 
       1  MAKRKYGRSY SLDDTDSCSN KVLIVPTGQS SSNAITDFSV RKAHACDRCR
      51  LKKIKCDGLK PNCSNCAKID FPCKTSDKLS RRGLPKGYTE LLEKEVVRLT
     101  NMNASSSANA NSNLPFINDT FYCFDNYNTQ SENQRFLGHL TWNILTNTFP
     151  TQKAVVFTDD RNNIDLQLQL LTNFLNLNGD FNHLPNFLLL KYDYNLQFLK
     201  NLLSVIIKDF FKRQNSLLLL LYPTNLWKNL LLDKINSTAM TGEPITLLAL
     251  LYIIQFTWSC FDDFKLFKVT KLIVSLTTNS KLDLKVLQLV NLSIFYFMGA
     301  SVDSCKSKSS LTEHSNVNSV IWTNDLLNLN FTNILNMGLY INPKNLIPIS
     351  GNNNNNKSNE EDDRIVTFWC FQFLSSWWSL IQGLPKSNFL TEEFQPKSIS
     401  VLEIPRLKPF EILLNFIIYS LDGCNLLNIS SLNVSDPNFQ FFQNELESFK
     451  KNLLLWNLYH NLSDHDNFRF LTSSSNKKLT TNLLLKNLTG LNHKLNQPDF
     501  VEIQLTLFYL SLKLMTLKEG DQDLKKEDIS LEILSLYFLI LTDDSNNDDN
     551  QQLQPQQLNL YHFTPFNSID IIDLCLNNLN NWSLSLKYES GQNQPHSSKI
     601  KFEKFQNFLN HWCPIWYYDE FSTNPFLQIL KINFKLLPFE TIHYSQEEQR
     651  LLISLNKLRY LDAVSSFNSS SVKSNFASKV NTQLNLLQHS SSNSNFLDAS
     701  PYDFNKIFMN NFENYDYETD EGYAEDDDEE DSDSDNSLPL EIPFKKSKNK
     751  CKNRNKELSQ RLSLFENRDS NSVDFNTDTN LNLNPDSPSV TSSKKKYLDH
     801  IILDNRDIVS NHDSSKQKFK IQNILNSTF*

external links for Sip4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sip4p
1) Lesage P, et al.  (1996) Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol Cell Biol 16(5):1921-8
2) Yang X, et al.  (1992) A protein kinase substrate identified by the two-hybrid system. Science 257(5070):680-2
3) Vincent O and Carlson M  (1998) Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes. EMBO J 17(23):7002-8
4) Roth S, et al.  (2004) Transcriptional activators Cat8 and Sip4 discriminate between sequence variants of the carbon source-responsive promoter element in the yeast Saccharomyces cerevisiae. Curr Genet 45(3):121-8