PRY1/YJL079C Protein Information

Standard Name	Pry1p 1
Systematic Name	Yjl079cp
ORF Classification	Verified
Description	Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication (2, 3)
Name Description	Pathogen Related in Yeast 1

Experimental Data
Molecules/cell	556 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	299
Molecular Weight (Da)	30,634
Isoelectric Point (pI)	4.3

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pry1p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000132423 \| P47032 MIPS: YJL079C NCBI: 1008240 \| 1352994 \| 45270502 \| 6322382 \| 895901 \| 929877 \| NP_012456.1 GenBank/EMBL/DDBJ: DAA08720.1 \| AY558306 \| X83502 \| X88851 \| Z49354

Amino Acid Sequence (or in FASTA format)
1 MKLSKLSILT SALATSALAA PAVVTVTEHA HEAAVVTVQG VVYVENGQTR 51 TTYETLAPAS TATPTSTATA LVAPPVAPSS ASSNSDVVLS ALKNLASVWG 101 KTTDSTTTLT SSESTSQSLA QATTTSTPAA ASTTSTPAAT TTTSQAAATS 151 SASSSDSDLS DFASSVLAEH NKKRALHKDT PALSWSDTLA SYAQDYADNY 201 DCSGTLTHSG GPYGENLALG YDGPAAVDAW YNEISNYDFS NPGFSSNTGH 251 FTQVVWKSTT QVGCGIKTCG GAWGDYVICS YDPAGNYEGE YADNVEPLA*

Amino Acid Sequence (or in FASTA format)

       1  MKLSKLSILT SALATSALAA PAVVTVTEHA HEAAVVTVQG VVYVENGQTR
      51  TTYETLAPAS TATPTSTATA LVAPPVAPSS ASSNSDVVLS ALKNLASVWG
     101  KTTDSTTTLT SSESTSQSLA QATTTSTPAA ASTTSTPAAT TTTSQAAATS
     151  SASSSDSDLS DFASSVLAEH NKKRALHKDT PALSWSDTLA SYAQDYADNY
     201  DCSGTLTHSG GPYGENLALG YDGPAAVDAW YNEISNYDFS NPGFSSNTGH
     251  FTQVVWKSTT QVGCGIKTCG GAWGDYVICS YDPAGNYEGE YADNVEPLA*

external links for Pry1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pry1p

1)	Ku, T. et al. (1996) Characterization of the PRY Genes: Yeast homologs of the plant PR-1 proteins. Unpublished
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Choudhary V and Schneiter R (2012) Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. Proc Natl Acad Sci U S A 109(42):16882-7
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41