YHC3/YJL059W Protein Information

Standard Name	Yhc3p
Systematic Name	Yjl059wp
Alias	Btn1p 1
ORF Classification	Verified
Description	Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) (1, 2, 3, 4, 5)
Name Description	Yeast Homolog of human Cln3 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	408
Molecular Weight (Da)	46,383
Isoelectric Point (pI)	7.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Yhc3p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000126B17 \| P47040 MIPS: YJL059W NCBI: 1008203 \| 1352987 \| 3063665 \| 51013729 \| 6322402 \| NP_012476.1 \| NM_001181492.1 GenBank/EMBL/DDBJ: DAA08739.1 \| AF058447 \| AY693139 \| Z49334

Amino Acid Sequence (or in FASTA format)
1 MSDKSHQIYC YFWLFGLINN VLYVVILSAA VDIVGPTLPK SLVLLADIFP 51 SLAIKLCSPF FIDRIKYSYR IWSLITMSCL GMFLVSFKNL FVCLLGISFA 101 SISSGFGEVT FLQLTHYYKQ ISLNGWSSGT GGAGIIGGAS YMFLTSIFKV 151 PVKLTLLVFS LLPFAFLFYF KLESNDTNLT YQSLQQIDEA EDDQLVPFPV 201 AFTHTNASQS LYSTRQHILQ TVKRLRRLVF PYMVPLTTVY LFEYLINQAV 251 APTLLFPING DERSKSMPFF FHKYRDIYVT YGTLYQLGVF ISRSFGHLMR 301 MRSLYILAFL QGVNLCITVL QSWFYVTHSP WAVMILIFYE GFLGGASYVN 351 TFLNILEQED PDETEFAMGA VSIADSFGVF LAALLGLGLE PKLCRHQIAD 401 DRPWCRME*

Amino Acid Sequence (or in FASTA format)

       1  MSDKSHQIYC YFWLFGLINN VLYVVILSAA VDIVGPTLPK SLVLLADIFP
      51  SLAIKLCSPF FIDRIKYSYR IWSLITMSCL GMFLVSFKNL FVCLLGISFA
     101  SISSGFGEVT FLQLTHYYKQ ISLNGWSSGT GGAGIIGGAS YMFLTSIFKV
     151  PVKLTLLVFS LLPFAFLFYF KLESNDTNLT YQSLQQIDEA EDDQLVPFPV
     201  AFTHTNASQS LYSTRQHILQ TVKRLRRLVF PYMVPLTTVY LFEYLINQAV
     251  APTLLFPING DERSKSMPFF FHKYRDIYVT YGTLYQLGVF ISRSFGHLMR
     301  MRSLYILAFL QGVNLCITVL QSWFYVTHSP WAVMILIFYE GFLGGASYVN
     351  TFLNILEQED PDETEFAMGA VSIADSFGVF LAALLGLGLE PKLCRHQIAD
     401  DRPWCRME*

external links for Yhc3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Yhc3p

1)	Pearce DA and Sherman F (1997) BTN1, a yeast gene corresponding to the human gene responsible for Batten's disease, is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase. Yeast 13(8):691-7
2)	Mitchison HM, et al. (1997) Structure of the CLN3 gene and predicted structure, location and function of CLN3 protein. Neuropediatrics 28(1):12-4
3)	Croopnick JB, et al. (1998) The subcellular location of the yeast Saccharomyces cerevisiae homologue of the protein defective in the juvenile form of Batten disease. Biochem Biophys Res Commun 250(2):335-41
4)	Kim Y, et al. (2003) A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease. Proc Natl Acad Sci U S A 100(26):15458-62
5)	Kim Y, et al. (2005) Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae. Eukaryot Cell 4(2):281-8