IKS1/YJL057C Protein Information Help

Standard Name Iks1p 1
Systematic Name Yjl057cp
ORF Classification Verified
Description Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p (1, 2, 3, 4, 5)
Experimental Data
Molecules/cell 892 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 667
Molecular Weight (Da) 75,327
Isoelectric Point (pI) 6.42

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Iks1p (InterPro)
Physical Interactions There are 67 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012DEB8 | P47042
MIPS: YJL057C
NCBI: 1008199 | 1346384 | 398364503 | NP_012478.3 | NM_001181490.3
GenBank/EMBL/DDBJ: DAA08741.1 | Z49332
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSLVPYEEGS LILDDPNSKS VVVVNPTSGT LSFFQQDNSN NDSELNEDQT
      51  ASLSALDFPS GIHQYKSPIA SYVCPQCGTE INPDIINRRQ LHRRASAGVE
     101  SESSRLSIPE NTVPLGFEFA NSSFSRRYFQ SLERNHRHYA LQNDSNNKQG
     151  QFSKNKYFIP DDLFIPGYFR KFFKILSLLG NGARGSVYKV VHTIGNTELG
     201  VFALKKIPIG NDMEWFNKCI REVKALSSLT HKSANLITYN HVWLEMDSSV
     251  GFVRSIDGSQ SDSQEEVPCI FILQQYCSGG NLEDCILRKV FNRFSDTESP
     301  EERKKKFRTR KKNHGKSGEV GLSTEQLVSI IRDIARGLHE LHSIGLIHRD
     351  LKPSNCLLLT PFKSDNENDN VYDREHNSDE FFPSIVIGDL GESQLEGESR
     401  LGTGCTGTLE FTAPDLIIQG RPVSSSTLPS RSSHTYNEYT FASDMYSLGM
     451  ICYFIVFGEL PFEPQLDIVD LKVRIKNFRF DTEGMIEKHQ AMKLKPIDRR
     501  IFHLMDALLQ PNNDARPTAK TVEETLDEML INSKPGKKFW KENVDSTLNF
     551  STISEVNENT NSFTDDYIDG DNVTLSLPAP EENLSTVSTQ NLQKYSALNR
     601  TIQVCYKLVS MILTIIIFKC TKTGSWLSYM SLILLGMVFK SPADERGKHA
     651  RALVLLAFIA ACKKYIY*

external links for Iks1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Iks1p
1) Rieger KJ, et al.  (1999) Chemotyping of yeast mutants using robotics. Yeast 15(10B):973-86
2) Burchett SA, et al.  (2002) Regulation of stress response signaling by the N-terminal dishevelled/EGL-10/pleckstrin domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae. J Biol Chem 277(25):22156-67
3) Mollapour M, et al.  (2004) Screening the yeast deletant mutant collection for hypersensitivity and hyper-resistance to sorbate, a weak organic acid food preservative. Yeast 21(11):927-46
4) Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84
5) Sakaki K, et al.  (2003) Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae. J Biochem 134(3):373-84
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41