ZAP1/YJL056C Protein Information Help

Standard Name Zap1p 1
Systematic Name Yjl056cp
Alias Zrg10p 2
ORF Classification Verified
Description Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains (1, 3, 4, 5)
Name Description Zinc-responsive Activator Protein 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 880
Molecular Weight (Da) 98,865
Isoelectric Point (pI) 7

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Zap1p (InterPro)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013C375 | P47043
MIPS: YJL056C
NCBI: 1008197 | 1352985 | 159163699 | 6322405 | NP_012479.1
GenBank/EMBL/DDBJ: DAA08742.1 | Z49331
Amino Acid Sequence (or in FASTA format)
 
       1  MDALTPRDSP KRDDSMATSA ATAASAKPDA LTIGKEGIVH GHIHNYNNLT
      51  YIHGHLHHSA PVNDSSASAT PAAAAVADAA TSAFASGASH DMGGDCHVNE
     101  KCKEYTDCQH FEFLNYHNNP SLTKYNDTAT YNSNNHSFAN NFHSVASDPT
     151  SPQQNSKSDL PRRKDSWFND DLILLPSSKK NKPNPPPGSD DCYCTPKILE
     201  ICCDETHPKS EANIKQGESD QPTKKDISEN GNDVAIFTDV KNDHLMPNFN
     251  LHDQYCNSTN HDSHNHNNTV PDSFSQLMSH LSEIDCDLTC DTPCTASTSA
     301  TSGHKFVQDH QSSNNDDVFH KYCKFCEEST DNQPCSKHMH LESKPPQLPP
     351  KCSSLRKPTN TLQGTNHAYH EHILNTDMDL KILEDLCNIS SLYEVPFGKH
     401  INHHDHNNAG NGCDGSSTGN NENGNQTMNL LLSSINRCNP KNNLNGSNNN
     451  TAGATSTDHQ HHHHRIQFHS HKPNRNNIVN NSGISAANTT ADLTNNDLND
     501  LISREYSYER FRNQSEPPSL PKVTHQNQKN RRSWPTKDLE STDFSSLEDS
     551  LPSSISPPIQ TTSTINFNWC FKEEKNNDLK CKWKECPESC SSLFDLQRHL
     601  LKDHVSQDFK HPMEPLACNW EDCDFLGDDT CSIVNHINCQ HGINFDIQFA
     651  NPDSFLPGSI SKEKHHLLHC PNPQTHEVSK ADGAPDMTSA NDVSNIPPIK
     701  QPEQVICQWD GCNKSFSSAQ ELNDHLEAVH LTRGKSEYQC LWHDCHRTFP
     751  QRQKLIRHLK VHSKYKPYKC KTCKRCFSSE ETLVQHTRTH SGEKPYKCHI
     801  CNKKFAISSS LKIHIRTHTG EKPLQCKICG KRFNESSNLS KHIKTHQKKY
     851  KCSDCSKSFD DLGKLNSQKV KCALERKPYL *

external links for Zap1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Zap1p
1) Zhao H and Eide DJ  (1997) Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell Biol 17(9):5044-52
2) Yuan DS  (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
3) Zhao H, et al.  (1998) Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements. J Biol Chem 273(44):28713-20
4) Evans-Galea MV, et al.  (2003) Two of the five zinc fingers in the Zap1 transcription factor DNA binding domain dominate site-specific DNA binding. Biochemistry 42(4):1053-61
5) Wu CY, et al.  (2009) Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency. J Biol Chem 284(40):27544-56