UBX6/YJL048C Protein Information

Standard Name	Ubx6p 1
Systematic Name	Yjl048cp
Alias	Cui2p 2
ORF Classification	Verified
Description	UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description	UBiquitin regulatory X 1

Experimental Data
Molecules/cell	1340 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	396
Molecular Weight (Da)	45,016
Isoelectric Point (pI)	8.8

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ubx6p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B54F \| P47049 MIPS: YJL048C NCBI: 1008181 \| 1352978 \| 51012829 \| 6322413 \| NP_012487.1 GenBank/EMBL/DDBJ: DAA08751.1 \| AY692689 \| Z49323

Amino Acid Sequence (or in FASTA format)
1 MYEMSGIDSL FHDRVVHDYS HTSEQVIVVY ISSAAGDNSW LHQWFKPGNL 51 SDEERENILW VRLVNGTKEC LLFKSIFPSS SAPSINILQN GLLECSIQGN 101 SLSREQDPWE TFINGLQSVF KGQVTKRKLF SKSNEEYQRV KRMIQNDKLE 151 RKYVFQNTND PQRKPQKWKQ LTVTDNVSYK SQKGFLAQNY CTLQLKLPNG 201 YTISNTFPPQ TKLHKVRMWL DYNCYDDGTP YLFHRNIPRV TLTRNDELKS 251 LQELDLLPRS TLILEPLEAN NKTFDYMEQS SLLHKVYSGL TSFWAKEPEV 301 DASSSRLGYQ RLGTNVSNSA NYSLQKLSSL DMVSDGGGGG GGDSMTPSAY 351 TTPRMYPSNG TSQLRQNVSE LNLSSNNSAS NTKVRTLGYS NNNGNN*

Amino Acid Sequence (or in FASTA format)

       1  MYEMSGIDSL FHDRVVHDYS HTSEQVIVVY ISSAAGDNSW LHQWFKPGNL
      51  SDEERENILW VRLVNGTKEC LLFKSIFPSS SAPSINILQN GLLECSIQGN
     101  SLSREQDPWE TFINGLQSVF KGQVTKRKLF SKSNEEYQRV KRMIQNDKLE
     151  RKYVFQNTND PQRKPQKWKQ LTVTDNVSYK SQKGFLAQNY CTLQLKLPNG
     201  YTISNTFPPQ TKLHKVRMWL DYNCYDDGTP YLFHRNIPRV TLTRNDELKS
     251  LQELDLLPRS TLILEPLEAN NKTFDYMEQS SLLHKVYSGL TSFWAKEPEV
     301  DASSSRLGYQ RLGTNVSNSA NYSLQKLSSL DMVSDGGGGG GGDSMTPSAY
     351  TTPRMYPSNG TSQLRQNVSE LNLSSNNSAS NTKVRTLGYS NNNGNN*

external links for Ubx6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ubx6p

1)	Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24
2)	Decottignies A, et al. (2004) Binding of Cdc48p to a ubiquitin-related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation. Yeast 21(2):127-39
3)	Santiago TC and Mamoun CB (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30
4)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41