HCA4/YJL033W Protein Information Help

Standard Name Hca4p
Systematic Name Yjl033wp
Alias Dbp4p 1 , Ecm24p
ORF Classification Verified
Description DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis (1, 2, 3)
Name Description Helicase CA 2
Experimental Data
Molecules/cell 7900 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 770
Molecular Weight (Da) 87,192
Isoelectric Point (pI) 7.44

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hca4p (InterPro)
Physical Interactions There are 106 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000005301C | P20448
MIPS: YJL033W
NCBI: 1008155 | 1170186 | 1619952 | 51013687 | 6322427 | NP_012501.1 | NM_001181467.1
GenBank/EMBL/DDBJ: DAA08766.1 | AY693118 | U72149 | Z49308
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.13 [RNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MAKKNRLNTT QRKTLRQKED EYIENLKTKI DEYDPKITKA KFFKDLPISD
      51  PTLKGLRESS FIKLTEIQAD SIPVSLQGHD VLAAAKTGSG KTLAFLVPVI
     101  EKLYREKWTE FDGLGALIIS PTRELAMQIY EVLTKIGSHT SFSAGLVIGG
     151  KDVKFELERI SRINILIGTP GRILQHLDQA VGLNTSNLQM LVLDEADRCL
     201  DMGFKKTLDA IVSTLSPSRQ TLLFSATQSQ SVADLARLSL TDYKTVGTHD
     251  VMDGSVNKEA STPETLQQFY IEVPLADKLD ILFSFIKSHL KCKMIVFLSS
     301  SKQVHFVYET FRKMQPGISL MHLHGRQKQR ARTETLDKFN RAQQVCLFAT
     351  DVVARGIDFP AVDWVVQVDC PEDVDTYIHR VGRCARYGKK GKSLIMLTPQ
     401  EQEAFLKRLN ARKIEPGKLN IKQSKKKSIK PQLQSLLFKD PELKYLGQKA
     451  FISYVRSIYV QKDKQVFKFD ELPTEEFAYS LGLPGAPKIK MKGMKTIEQA
     501  KERKNAPRQL AFLSKANEDG EVIEDKSKQP RTKYDKMFER KNQTILSEHY
     551  LNITKAQAQE DEDDDFISVK RKDHEINEAE LPALTLPTSR RAQKKALSKK
     601  ASLASKGNAS KLIFDDEGEA HPVYELEDEE EFHKRGDAEV QKTEFLTKES
     651  AVMADIDNID KQVAKEKKQE KKRKRLEAMR REMEAAMEEE ISGDEEEGKT
     701  VAYLGTGNLS DDMSDGDMPD SEGHLKKKAR TVDYSHGHNP SNSVDDDIIE
     751  VEEPQTLEDL ESLTAKLIQG *

external links for Hca4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Hca4p
1) Liang WQ, et al.  (1997) The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein. Mol Cell Biol 17(7):4124-32
2) Chang TH, et al.  (1990) Identification of five putative yeast RNA helicase genes. Proc Natl Acad Sci U S A 87(4):1571-5
3) Garcia I, et al.  (2012) Duplex destabilization by four ribosomal DEAD-box proteins. Biochemistry 51(50):10109-18
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41