CCT8/YJL008C Protein Information

Standard Name	Cct8p
Systematic Name	Yjl008cp
ORF Classification	Verified
Description	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo (1, 2)
Name Description	Chaperonin Containing TCP-1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	568
Molecular Weight (Da)	61,662
Isoelectric Point (pI)	5.53

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cct8p (InterPro)
Physical Interactions	There are 52 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F9A \| P47079 MIPS: YJL008C NCBI: 1006721 \| 1174622 \| 339717523 \| 339717531 \| 388326558 \| 388326566 \| 6322452 \| NP_012526.1 GenBank/EMBL/DDBJ: DAA08784.1 \| Z49284

Amino Acid Sequence (or in FASTA format)
1 MSLRLPQNPN AGLFKQGYNS YSNADGQIIK SIAAIRELHQ MCLTSMGPCG 51 RNKIIVNHLG KIIITNDAAT MLRELDIVHP AVKVLVMATE QQKIDMGDGT 101 NLVMILAGEL LNVSEKLISM GLSAVEIIQG YNMARKFTLK ELDEMVVGEI 151 TDKNDKNELL KMIKPVISSK KYGSEDILSE LVSEAVSHVL PVAQQAGEIP 201 YFNVDSIRVV KIMGGSLSNS TVIKGMVFNR EPEGHVKSLS EDKKHKVAVF 251 TCPLDIANTE TKGTVLLHNA QEMLDFSKGE EKQIDAMMKE IADMGVECIV 301 AGAGVGELAL HYLNRYGILV LKVPSKFELR RLCRVCGATP LPRLGAPTPE 351 ELGLVETVKT MEIGGDRVTV FKQEQGEISR TSTIILRGAT QNNLDDIERA 401 IDDGVAAVKG LMKPSGGKLL PGAGATEIEL ISRITKYGER TPGLLQLAIK 451 QFAVAFEVVP RTLAETAGLD VNEVLPNLYA AHNVTEPGAV KTDHLYKGVD 501 IDGESDEGVK DIREENIYDM LATKKFAINV ATEAATTVLS IDQIIMAKKA 551 GGPRAPQGPR PGNWDQED*

Amino Acid Sequence (or in FASTA format)

       1  MSLRLPQNPN AGLFKQGYNS YSNADGQIIK SIAAIRELHQ MCLTSMGPCG
      51  RNKIIVNHLG KIIITNDAAT MLRELDIVHP AVKVLVMATE QQKIDMGDGT
     101  NLVMILAGEL LNVSEKLISM GLSAVEIIQG YNMARKFTLK ELDEMVVGEI
     151  TDKNDKNELL KMIKPVISSK KYGSEDILSE LVSEAVSHVL PVAQQAGEIP
     201  YFNVDSIRVV KIMGGSLSNS TVIKGMVFNR EPEGHVKSLS EDKKHKVAVF
     251  TCPLDIANTE TKGTVLLHNA QEMLDFSKGE EKQIDAMMKE IADMGVECIV
     301  AGAGVGELAL HYLNRYGILV LKVPSKFELR RLCRVCGATP LPRLGAPTPE
     351  ELGLVETVKT MEIGGDRVTV FKQEQGEISR TSTIILRGAT QNNLDDIERA
     401  IDDGVAAVKG LMKPSGGKLL PGAGATEIEL ISRITKYGER TPGLLQLAIK
     451  QFAVAFEVVP RTLAETAGLD VNEVLPNLYA AHNVTEPGAV KTDHLYKGVD
     501  IDGESDEGVK DIREENIYDM LATKKFAINV ATEAATTVLS IDQIIMAKKA
     551  GGPRAPQGPR PGNWDQED*

external links for Cct8p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cct8p

1)	Stoldt V, et al. (1996) Review: the Cct eukaryotic chaperonin subunits of Saccharomyces cerevisiae and other yeasts. Yeast 12(6):523-9
2)	Kim S, et al. (1994) Cystosolic chaperonin subunits have a conserved ATPase domain but diverged polypeptide-binding domains. Trends Biochem Sci 19(12):543-8