CTK2/YJL006C Protein Information

Standard Name	Ctk2p
Systematic Name	Yjl006cp
ORF Classification	Verified
Description	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity (1, 2)
Name Description	Carboxy-Terminal domain Kinase 1

Experimental Data
Molecules/cell	1590 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	323
Molecular Weight (Da)	37,904
Isoelectric Point (pI)	8.05

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ctk2p (InterPro)
Physical Interactions	There are 51 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000005323C \| P46962 MIPS: YJL006C NCBI: 1006716 \| 1016080 \| 1169121 \| 6322454 \| NP_012528.1 GenBank/EMBL/DDBJ: DAA08785.1 \| U30295 \| Z49281

Amino Acid Sequence (or in FASTA format)
1 MPSTFESQLF FSRPFLSKRQ IQRAQKNTIS DYRNYNQKKL AVFKFLSDLC 51 VQLKFPRKTL ETAVYFYQRY HLFNRFETEV CYTVATSCLT LGCKEVETIK 101 KTNDICTLSL RLRNVVKINT DILENFKKRV FQIELRILES CSFDYRVNNY 151 VHIDEYVIKI GRELSFDYKL CNLAWVIAYD ALKLETILVI PQHSIALAIL 201 KIAYELLDNK NWSSKRYSLF ETDEKSVNEA YFDIVNFYIN SFDMCDLQRH 251 LPADLLPIGV ERFMELKKNA GPESGLPQIP DHLLNADPYI TITRDNNVQE 301 RRYVLSLELI NGESSINSST RHA*

Amino Acid Sequence (or in FASTA format)

       1  MPSTFESQLF FSRPFLSKRQ IQRAQKNTIS DYRNYNQKKL AVFKFLSDLC
      51  VQLKFPRKTL ETAVYFYQRY HLFNRFETEV CYTVATSCLT LGCKEVETIK
     101  KTNDICTLSL RLRNVVKINT DILENFKKRV FQIELRILES CSFDYRVNNY
     151  VHIDEYVIKI GRELSFDYKL CNLAWVIAYD ALKLETILVI PQHSIALAIL
     201  KIAYELLDNK NWSSKRYSLF ETDEKSVNEA YFDIVNFYIN SFDMCDLQRH
     251  LPADLLPIGV ERFMELKKNA GPESGLPQIP DHLLNADPYI TITRDNNVQE
     301  RRYVLSLELI NGESSINSST RHA*

external links for Ctk2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ctk2p

1)	Sterner DE, et al. (1995) The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol Cell Biol 15(10):5716-24
2)	Rother S and Strasser K (2007) The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev 21(11):1409-21
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41