CYR1/YJL005W Protein Information

Standard Name	Cyr1p
Systematic Name	Yjl005wp
Alias	Cdc35p , Hsr1p , Sra4p , Tsm0185p , Fil1p
ORF Classification	Verified
Description	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation (1, 2, 3, 4, 5)
Name Description	CYclic AMP Requirement 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	2,026
Molecular Weight (Da)	227,832
Isoelectric Point (pI)	7.29

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cyr1p (InterPro)
Physical Interactions	There are 54 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000128896 \| P08678 MIPS: YJL005W NCBI: 1006714 \| 1169151 \| 171360 \| 3488 \| 398364701 \| 854568 \| NP_012529.3 GenBank/EMBL/DDBJ: DAA08786.1 \| M12057 \| X03449 \| X87611 \| Z49280
External Classifications	EC: 4.6.1.1 [Adenylate cyclase]

Amino Acid Sequence (or in FASTA format)
1 MSSKPDTGSE ISGPQRQEEQ EQQIEQSSPT EANDRSIHDE VPKVKKRHEQ 51 NSGHKSRRNS AYSYYSPRSL SMTKSRESIT PNGMDDVSIS NVEHPRPTEP 101 KIKRGPYLLK KTLSSLSMTS ANSTHDDNKD HGYALNSSKT HNYTSTHNHH 151 DGHHDHHHVQ FFPNRKPSLA ETLFKRFSGS NSHDGNKSGK ESKVANLSLS 201 TVNPAPANRK PSKDSTLSNH LADNVPSTLR RKVSSLVRGS SVHDINNGIA 251 DKQIRPKAVA QSENTLHSSD VPNSKRSHRK SFLLGSTSSS SSRRGSNVSS 301 MTNSDSASMA TSGSHVLQHN VSNVSPTTKS KDSVNSESAD HTNNKSEKVT 351 PEYNENIPEN SNSDNKREAT TPTIETPISC KPSLFRLDTN LEDVTDITKT 401 VPPTAVNSTL NSTHGTETAS PKTVIMPEGP RKSVSMADLS VAAAAPNGEF 451 TSTSNDRSQW VAPQSWDVET KRKKTKPKGR SKSRRSSIDA DELDPMSPGP 501 PSKKDSRHHH DRKDNESMVT AGDSNSSFVD ICKENVPNDS KTALDTKSVN 551 RLKSNLAMSP PSIRYAPSNL DGDYDTSSTS SSLPSSSISS EDTSSCSDSS 601 SYTNAYMEAN REQDNKTPIL NKTKSYTKKF TSSSVNMNSP DGAQSSGLLL 651 QDEKDDEVEC QLEHYYKDFS DLDPKRHYAI RIFNTDDTFT TLSCTPATTV 701 EEIIPALKRK FNITAQGNFQ ISLKVGKLSK ILRPTSKPIL IERKLLLLNG 751 YRKSDPLHIM GIEDLSFVFK FLFHPVTPSH FTPEQEQRIM RSEFVHVDLR 801 NMDLTTPPII FYQHTSEIES LDVSNNANIF LPLEFIESSI KLLSLRMVNI 851 RASKFPSNIT KAYKLVSLEL QRNFIRKVPN SIMKLSNLTI LNLQCNELES 901 LPAGFVELKN LQLLDLSSNK FMHYPEVINY CTNLLQIDLS YNKIQSLPQS 951 TKYLVKLAKM NLSHNKLNFI GDLSEMTDLR TLNLRYNRIS SIKTNASNLQ 1001 NLFLTDNRIS NFEDTLPKLR ALEIQENPIT SISFKDFYPK NMTSLTLNKA 1051 QLSSIPGELL TKLSFLEKLE LNQNNLTRLP QEISKLTKLV FLSVARNKLE 1101 YIPPELSQLK SLRTLDLHSN NIRDFVDGME NLELTSLNIS SNAFGNSSLE 1151 NSFYHNMSYG SKLSKSLMFF IAADNQFDDA MWPLFNCFVN LKVLNLSYNN 1201 FSDVSHMKLE SITELYLSGN KLTTLSGDTV LKWSSLKTLM LNSNQMLSLP 1251 AELSNLSQLS VFDVGANQLK YNISNYHYDW NWRNNKELKY LNFSGNRRFE 1301 IKSFISHDID ADLSDLTVLP QLKVLGLMDV TLNTTKVPDE NVNFRLRTTA 1351 SIINGMRYGV ADTLGQRDYV SSRDVTFERF RGNDDECLLC LHDSKNQNAD 1401 YGHNISRIVR DIYDKILIRQ LERYGDETDD NIKTALRFSF LQLNKEINGM 1451 LNSVDNGADV ANLSYADLLS GACSTVIYIR GKKLFAANLG DCMAILSKNN 1501 GDYQTLTKQH LPTKREEYER IRISGGYVNN GKLDGVVDVS RAVGFFDLLP 1551 HIHASPDISV VTLTKADEML IVATHKLWEY MDVDTVCDIA RENSTDPLRA 1601 AAELKDHAMA YGCTENITIL CLALYENIQQ QNRFTLNKNS LMTRRSTFED 1651 TTLRRLQPEI SPPTGNLAMV FTDIKSSTFL WELFPNAMRT AIKTHNDIMR 1701 RQLRIYGGYE VKTEGDAFMV AFPTPTSGLT WCLSVQLKLL DAQWPEEITS 1751 VQDGCQVTDR NGNIIYQGLS VRMGIHWGCP VPELDLVTQR MDYLGPMVNK 1801 AARVQGVADG GQIAMSSDFY SEFNKIMKYH ERVVKGKESL KEVYGEEIIG 1851 EVLEREIAML ESIGWAFFDF GEHKLKGLET KELVTIAYPK ILASRHEFAS 1901 EDEQSKLINE TMLFRLRVIS NRLESIMSAL SGGFIELDSR TEGSYIKFNP 1951 KVENGIMQSI SEKDALLFFD HVITRIESSV ALLHLRQQRC SGLEICRNDK 2001 TSARSNIFNV VDELLQMVKN AKDLST*

Amino Acid Sequence (or in FASTA format)

       1  MSSKPDTGSE ISGPQRQEEQ EQQIEQSSPT EANDRSIHDE VPKVKKRHEQ
      51  NSGHKSRRNS AYSYYSPRSL SMTKSRESIT PNGMDDVSIS NVEHPRPTEP
     101  KIKRGPYLLK KTLSSLSMTS ANSTHDDNKD HGYALNSSKT HNYTSTHNHH
     151  DGHHDHHHVQ FFPNRKPSLA ETLFKRFSGS NSHDGNKSGK ESKVANLSLS
     201  TVNPAPANRK PSKDSTLSNH LADNVPSTLR RKVSSLVRGS SVHDINNGIA
     251  DKQIRPKAVA QSENTLHSSD VPNSKRSHRK SFLLGSTSSS SSRRGSNVSS
     301  MTNSDSASMA TSGSHVLQHN VSNVSPTTKS KDSVNSESAD HTNNKSEKVT
     351  PEYNENIPEN SNSDNKREAT TPTIETPISC KPSLFRLDTN LEDVTDITKT
     401  VPPTAVNSTL NSTHGTETAS PKTVIMPEGP RKSVSMADLS VAAAAPNGEF
     451  TSTSNDRSQW VAPQSWDVET KRKKTKPKGR SKSRRSSIDA DELDPMSPGP
     501  PSKKDSRHHH DRKDNESMVT AGDSNSSFVD ICKENVPNDS KTALDTKSVN
     551  RLKSNLAMSP PSIRYAPSNL DGDYDTSSTS SSLPSSSISS EDTSSCSDSS
     601  SYTNAYMEAN REQDNKTPIL NKTKSYTKKF TSSSVNMNSP DGAQSSGLLL
     651  QDEKDDEVEC QLEHYYKDFS DLDPKRHYAI RIFNTDDTFT TLSCTPATTV
     701  EEIIPALKRK FNITAQGNFQ ISLKVGKLSK ILRPTSKPIL IERKLLLLNG
     751  YRKSDPLHIM GIEDLSFVFK FLFHPVTPSH FTPEQEQRIM RSEFVHVDLR
     801  NMDLTTPPII FYQHTSEIES LDVSNNANIF LPLEFIESSI KLLSLRMVNI
     851  RASKFPSNIT KAYKLVSLEL QRNFIRKVPN SIMKLSNLTI LNLQCNELES
     901  LPAGFVELKN LQLLDLSSNK FMHYPEVINY CTNLLQIDLS YNKIQSLPQS
     951  TKYLVKLAKM NLSHNKLNFI GDLSEMTDLR TLNLRYNRIS SIKTNASNLQ
    1001  NLFLTDNRIS NFEDTLPKLR ALEIQENPIT SISFKDFYPK NMTSLTLNKA
    1051  QLSSIPGELL TKLSFLEKLE LNQNNLTRLP QEISKLTKLV FLSVARNKLE
    1101  YIPPELSQLK SLRTLDLHSN NIRDFVDGME NLELTSLNIS SNAFGNSSLE
    1151  NSFYHNMSYG SKLSKSLMFF IAADNQFDDA MWPLFNCFVN LKVLNLSYNN
    1201  FSDVSHMKLE SITELYLSGN KLTTLSGDTV LKWSSLKTLM LNSNQMLSLP
    1251  AELSNLSQLS VFDVGANQLK YNISNYHYDW NWRNNKELKY LNFSGNRRFE
    1301  IKSFISHDID ADLSDLTVLP QLKVLGLMDV TLNTTKVPDE NVNFRLRTTA
    1351  SIINGMRYGV ADTLGQRDYV SSRDVTFERF RGNDDECLLC LHDSKNQNAD
    1401  YGHNISRIVR DIYDKILIRQ LERYGDETDD NIKTALRFSF LQLNKEINGM
    1451  LNSVDNGADV ANLSYADLLS GACSTVIYIR GKKLFAANLG DCMAILSKNN
    1501  GDYQTLTKQH LPTKREEYER IRISGGYVNN GKLDGVVDVS RAVGFFDLLP
    1551  HIHASPDISV VTLTKADEML IVATHKLWEY MDVDTVCDIA RENSTDPLRA
    1601  AAELKDHAMA YGCTENITIL CLALYENIQQ QNRFTLNKNS LMTRRSTFED
    1651  TTLRRLQPEI SPPTGNLAMV FTDIKSSTFL WELFPNAMRT AIKTHNDIMR
    1701  RQLRIYGGYE VKTEGDAFMV AFPTPTSGLT WCLSVQLKLL DAQWPEEITS
    1751  VQDGCQVTDR NGNIIYQGLS VRMGIHWGCP VPELDLVTQR MDYLGPMVNK
    1801  AARVQGVADG GQIAMSSDFY SEFNKIMKYH ERVVKGKESL KEVYGEEIIG
    1851  EVLEREIAML ESIGWAFFDF GEHKLKGLET KELVTIAYPK ILASRHEFAS
    1901  EDEQSKLINE TMLFRLRVIS NRLESIMSAL SGGFIELDSR TEGSYIKFNP
    1951  KVENGIMQSI SEKDALLFFD HVITRIESSV ALLHLRQQRC SGLEICRNDK
    2001  TSARSNIFNV VDELLQMVKN AKDLST*

external links for Cyr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Cyr1p

1)	Matsumoto K, et al. (1982) Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 79(7):2355-9
2)	Kataoka T, et al. (1985) DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell 43(2 Pt 1):493-505
3)	Casperson GF, et al. (1985) Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 82(15):5060-3
4)	Jacquet M and Camonis J (1985) [Control of the cell division cycle and sporulation in Saccharomyces cerevisiae by the cyclic AMP system] Biochimie 67(1):35-43
5)	Cannon JF and Tatchell K (1987) Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol 7(8):2653-63