MAL12/YGR292W Protein Information

Standard Name	Mal12p
Systematic Name	Ygr292wp
ORF Classification	Verified
Description	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose (1, 2, 3) Also known as: MALS 4
Name Description	MALtose fermentation

Experimental Data
Molecules/cell	5060 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	584
Molecular Weight (Da)	68,094
Isoelectric Point (pI)	5.51

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mal12p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012EAEA \| P53341 MIPS: YGR292W NCBI: 1708906 \| 398366435 \| NP_011808.3 GenBank/EMBL/DDBJ: DAA08378.1 \| Z73077
External Classifications	EC: 3.2.1.20 [Alpha-glucosidase]

Amino Acid Sequence (or in FASTA format)
1 MTISDHPETE PKWWKEATIY QIYPASFKDS NNDGWGDLKG ITSKLQYIKD 51 LGVDAIWVCP FYDSPQQDMG YDISNYEKVW PTYGTNEDCF ELIDKTHKLG 101 MKFITDLVIN HCSTEHEWFK ESRSSKTNPK RDWFFWRPPK GYDAEGKPIP 151 PNNWKSFFGG SAWTFDETTN EFYLRLFASR QVDLNWENED CRRAIFESAV 201 GFWLDHGVDG FRIDTAGLYS KRPGLPDSPI FDKTSKLQHP NWGSHNGPRI 251 HEYHQELHRF MKNRVKDGRE IMTVGEVAHG SDNALYTSAA RYEVSEVFSF 301 THVEVGTSPF FRYNIVPFTL KQWKEAIASN FLFINGTDSW ATTYIENHDQ 351 ARSITRFADD SPKYRKISGK LLTLLECSLT GTLYVYQGQE IGQINFKEWP 401 IEKYEDVDVK NNYEIIKKSF GKNSKEMKDF FKGIALLSRD HSRTPMPWTK 451 DKPNAGFTGP DVKPWFLLNE SFEQGINVEQ ESRDDDSVLN FWKRALQARK 501 KYKELMIYGY DFQFIDLDSD QIFSFTKEYE DKTLFAALNF SGEEIEFSLP 551 REGASLSFIL GNYDDTDVSS RVLKPWEGRI YLVK*

Amino Acid Sequence (or in FASTA format)

       1  MTISDHPETE PKWWKEATIY QIYPASFKDS NNDGWGDLKG ITSKLQYIKD
      51  LGVDAIWVCP FYDSPQQDMG YDISNYEKVW PTYGTNEDCF ELIDKTHKLG
     101  MKFITDLVIN HCSTEHEWFK ESRSSKTNPK RDWFFWRPPK GYDAEGKPIP
     151  PNNWKSFFGG SAWTFDETTN EFYLRLFASR QVDLNWENED CRRAIFESAV
     201  GFWLDHGVDG FRIDTAGLYS KRPGLPDSPI FDKTSKLQHP NWGSHNGPRI
     251  HEYHQELHRF MKNRVKDGRE IMTVGEVAHG SDNALYTSAA RYEVSEVFSF
     301  THVEVGTSPF FRYNIVPFTL KQWKEAIASN FLFINGTDSW ATTYIENHDQ
     351  ARSITRFADD SPKYRKISGK LLTLLECSLT GTLYVYQGQE IGQINFKEWP
     401  IEKYEDVDVK NNYEIIKKSF GKNSKEMKDF FKGIALLSRD HSRTPMPWTK
     451  DKPNAGFTGP DVKPWFLLNE SFEQGINVEQ ESRDDDSVLN FWKRALQARK
     501  KYKELMIYGY DFQFIDLDSD QIFSFTKEYE DKTLFAALNF SGEEIEFSLP
     551  REGASLSFIL GNYDDTDVSS RVLKPWEGRI YLVK*

external links for Mal12p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mal12p

1)	Chow T, et al. (1983) Identification and physical characterization of yeast maltase structural genes. Mol Gen Genet 191(3):366-71
2)	Charron MJ, et al. (1986) Structural and functional analysis of the MAL1 locus of Saccharomyces cerevisiae. Mol Cell Biol 6(11):3891-9
3)	Brown CA, et al. (2010) Rapid expansion and functional divergence of subtelomeric gene families in yeasts. Curr Biol 20(10):895-903
4)	Chow TH, et al. (1989) Structure of the multigene family of MAL loci in Saccharomyces. Mol Gen Genet 217(1):60-9
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41