YOR1/YGR281W Protein Information Help

Standard Name Yor1p 1
Systematic Name Ygr281wp
Alias Yrs1p 2
ORF Classification Verified
Description Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) (1, 2, 3, 4, 5)
Name Description Yeast Oligomycin Resistance 1
Experimental Data
Molecules/cell 3610 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,477
Molecular Weight (Da) 166,727
Isoelectric Point (pI) 7.65

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Yor1p (InterPro)
Transmembrane Domains There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 45 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000531C7 | P53049
MIPS: YGR281W
NCBI: 1323513 | 1730876 | 398366407 | NP_011797.3
GenBank/EMBL/DDBJ: DAA08369.1 | Z73066
External Classifications TC: 3.A.1.208 [The Conjugate Transporter-2 (CT2) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MTITVGDAVS ETELENKSQN VVLSPKASAS SDISTDVDKD TSSSWDDKSL
      51  LPTGEYIVDR NKPQTYLNSD DIEKVTESDI FPQKRLFSFL HSKKIPEVPQ
     101  TDDERKIYPL FHTNIISNMF FWWVLPILRV GYKRTIQPND LFKMDPRMSI
     151  ETLYDDFEKN MIYYFEKTRK KYRKRHPEAT EEEVMENAKL PKHTVLRALL
     201  FTFKKQYFMS IVFAILANCT SGFNPMITKR LIEFVEEKAI FHSMHVNKGI
     251  GYAIGACLMM FVNGLTFNHF FHTSQLTGVQ AKSILTKAAM KKMFNASNYA
     301  RHCFPNGKVT SFVTTDLARI EFALSFQPFL AGFPAILAIC IVLLIVNLGP
     351  IALVGIGIFF GGFFISLFAF KLILGFRIAA NIFTDARVTM MREVLNNIKM
     401  IKYYTWEDAY EKNIQDIRTK EISKVRKMQL SRNFLIAMAM SLPSIASLVT
     451  FLAMYKVNKG GRQPGNIFAS LSLFQVLSLQ MFFLPIAIGT GIDMIIGLGR
     501  LQSLLEAPED DPNQMIEMKP SPGFDPKLAL KMTHCSFEWE DYELNDAIEE
     551  AKGEAKDEGK KNKKKRKDTW GKPSASTNKA KRLDNMLKDR DGPEDLEKTS
     601  FRGFKDLNFD IKKGEFIMIT GPIGTGKSSL LNAMAGSMRK TDGKVEVNGD
     651  LLMCGYPWIQ NASVRDNIIF GSPFNKEKYD EVVRVCSLKA DLDILPAGDM
     701  TEIGERGITL SGGQKARINL ARSVYKKKDI YLFDDVLSAV DSRVGKHIMD
     751  ECLTGMLANK TRILATHQLS LIERASRVIV LGTDGQVDIG TVDELKARNQ
     801  TLINLLQFSS QNSEKEDEEQ EAVVAGELGQ LKYESEVKEL TELKKKATEM
     851  SQTANSGKIV ADGHTSSKEE RAVNSISLKI YREYIKAAVG KWGFIALPLY
     901  AILVVGTTFC SLFSSVWLSY WTENKFKNRP PSFYMGLYSF FVFAAFIFMN
     951  GQFTILCAMG IMASKWLNLR AVKRILHTPM SYIDTTPLGR ILNRFTKDTD
    1001  SLDNELTESL RLMTSQFANI VGVCVMCIVY LPWFAIAIPF LLVIFVLIAD
    1051  HYQSSGREIK RLEAVQRSFV YNNLNEVLGG MDTIKAYRSQ ERFLAKSDFL
    1101  INKMNEAGYL VVVLQRWVGI FLDMVAIAFA LIITLLCVTR AFPISAASVG
    1151  VLLTYVLQLP GLLNTILRAM TQTENDMNSA ERLVTYATEL PLEASYRKPE
    1201  MTPPESWPSM GEIIFENVDF AYRPGLPIVL KNLNLNIKSG EKIGICGRTG
    1251  AGKSTIMSAL YRLNELTAGK ILIDNVDISQ LGLFDLRRKL AIIPQDPVLF
    1301  RGTIRKNLDP FNERTDDELW DALVRGGAIA KDDLPEVKLQ KPDENGTHGK
    1351  MHKFHLDQAV EEEGSNFSLG ERQLLALTRA LVRQSKILIL DEATSSVDYE
    1401  TDGKIQTRIV EEFGDCTILC IAHRLKTIVN YDRILVLEKG EVAEFDTPWT
    1451  LFSQEDSIFR SMCSRSGIVE NDFENRS*

external links for Yor1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome TCDB
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Yor1p
1) Katzmann DJ, et al.  (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15(12):6875-83
2) Cui Z, et al.  (1996) The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions. J Biol Chem 271(25):14712-6
3) Decottignies A, et al.  (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273(20):12612-22
4) Rogers B, et al.  (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14
5) Epping EA and Moye-Rowley WS  (2002) Identification of interdependent signals required for anterograde traffic of the ATP-binding cassette transporter protein Yor1p. J Biol Chem 277(38):34860-9
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41