RNH70/YGR276C Protein Information

Standard Name	Rnh70p 1
Systematic Name	Ygr276cp
Alias	Rex1p 2 , Rna82p 3
ORF Classification	Verified
Description	3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts (2)
Name Description	RNase H 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	553
Molecular Weight (Da)	62,849
Isoelectric Point (pI)	7.21

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rnh70p (InterPro)
Physical Interactions	There are 28 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AFCF \| P53331 MIPS: YGR276C NCBI: 1323503 \| 1723780 \| 1945341 \| 2104899 \| 6321715 \| NP_011792.1 GenBank/EMBL/DDBJ: DAA08364.1 \| X84098 \| Z73061 \| Z73062
External Classifications	EC: 3.1.-.- [Hydrolases acting on ester bonds ]

Amino Acid Sequence (or in FASTA format)
1 MQVEGPDTNF VSDLALGSKK RRLSKTSVQE DDHTNVVSEV NKNKKKKKAK 51 PMTCTLLKSV VEKGIGIKDV RDMTQYLLQA ENNSPKWIDI CNRSSLQKMI 101 VLFIPGLQPD DFENGKNTFN EISDDNFKYI PGEIASTFHT FPVMAPGSKM 151 TLFSPYNSFI NVGLSKMEKI NKLKELQKKK KITINDLVLS EQQLVANDYP 201 LDSGDTNFDT DWVQTVDFTH GGSHIFALDC EMCLSEQGLV LTRISLVNFD 251 NEVIYEELVK PDVPIVDYLT RYSGITEEKL TVGAKKTLRE VQKDLLKIIS 301 RSDILIGHSL QNDLKVMKLK HPLVVDTAII YHHKAGDPFK PSLKYLSETF 351 LNKSIQNGEH DSVEDARACL ELTKLKILNG LAFGIGINTE NLFTKLHRFE 401 VKTVLLNDMI IKNHTEDDSK GQLIRCVEDD ETWTHIHENL NKDVKLIVGR 451 IKNLERSRNY NKKPRKETPS FDASMVLHDI GQHLTQLYEN ATPGTMILIM 501 SGTGDTRPWN NLSTELEFIQ DKKERLDKRR EREPEIVEAI KLARGGVASF 551 TVK*

Amino Acid Sequence (or in FASTA format)

       1  MQVEGPDTNF VSDLALGSKK RRLSKTSVQE DDHTNVVSEV NKNKKKKKAK
      51  PMTCTLLKSV VEKGIGIKDV RDMTQYLLQA ENNSPKWIDI CNRSSLQKMI
     101  VLFIPGLQPD DFENGKNTFN EISDDNFKYI PGEIASTFHT FPVMAPGSKM
     151  TLFSPYNSFI NVGLSKMEKI NKLKELQKKK KITINDLVLS EQQLVANDYP
     201  LDSGDTNFDT DWVQTVDFTH GGSHIFALDC EMCLSEQGLV LTRISLVNFD
     251  NEVIYEELVK PDVPIVDYLT RYSGITEEKL TVGAKKTLRE VQKDLLKIIS
     301  RSDILIGHSL QNDLKVMKLK HPLVVDTAII YHHKAGDPFK PSLKYLSETF
     351  LNKSIQNGEH DSVEDARACL ELTKLKILNG LAFGIGINTE NLFTKLHRFE
     401  VKTVLLNDMI IKNHTEDDSK GQLIRCVEDD ETWTHIHENL NKDVKLIVGR
     451  IKNLERSRNY NKKPRKETPS FDASMVLHDI GQHLTQLYEN ATPGTMILIM
     501  SGTGDTRPWN NLSTELEFIQ DKKERLDKRR EREPEIVEAI KLARGGVASF
     551  TVK*

external links for Rnh70p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rnh70p

1)	Frank P, et al. (1999) Purification of Saccharomyces cerevisiae RNase H(70) and identification of the corresponding gene. FEBS Lett 450(3):251-6
2)	van Hoof A, et al. (2000) Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast. EMBO J 19(6):1357-65
3)	Piper PW, et al. (1984) Processing of the 3' sequence extensions upon the 5S rRNA of a mutant yeast in Xenopus laevis germinal vesicle extract. Eur J Biochem 141(1):115-8