SLH1/YGR271W Protein Information Help

Standard Name Slh1p 1
Systematic Name Ygr271wp
ORF Classification Verified
Description Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses (2, 3)
Name Description SKI2-Like Helicase 1
Experimental Data
Molecules/cell 486 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,967
Molecular Weight (Da) 224,849
Isoelectric Point (pI) 6.58

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Slh1p (InterPro)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0001779B10 | P53327
MIPS: YGR271W
NCBI: 1143249 | 1323493 | 1723776 | 347595711 | 398366359 | NP_011787.4 | NM_001181400.4
GenBank/EMBL/DDBJ: DAA08359.2 | U35242 | Z73056
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.13 [RNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSTEYSADSS KSFMIAMQSM IDTSQTFNLD RSKISLPDFD DELKKVQKDE
      51  QNQRTELTVL SQDRNDWDDI FEEFKDISFA QLQSIIDSYK TKNAVAVYKK
     101  IGKLINEAET TLSSNVLLET VLQMVYKHQK QELEKELLDF LGTGNIDLVS
     151  LLLQHRRMIV ATPIETTILL IKNAVNSTPE FLTQQDIRNQ VLKSAEDAKN
     201  RKLNPATKII KYPHVFRKYE AGSTTAMAFA GQKFTLPVGT TRMSYNTHEE
     251  IIIPAADQAS NKNYLYTKLL KISDLDHFCK TVFPYETLNQ IQSLVYPVAY
     301  KTNENMLICA PTGAGKTDIA LLTIINTIKQ FSVVNGENEI DIQYDDFKVI
     351  YVAPLKALAA EIVDKFSKKL APFNIQVREL TGDMQLTKAE ILATQVIVTT
     401  PEKWDVVTRK ANGDNDLVSK VKLLIIDEVH LLHEDRGSVI ETLVARTLRQ
     451  VESSQSMIRI IGLSATLPNF MDVADFLGVN RQIGMFYFDQ SFRPKPLEQQ
     501  LLGCRGKAGS RQSKENIDKV AYDKLSEMIQ RGYQVMVFVH SRKETVKSAR
     551  NFIKLAESNH EVDLFAPDPI EKDKYSRSLV KNRDKDMKEI FQFGFGIHHA
     601  GMARSDRNLT EKMFKDGAIK VLCCTATLAW GVNLPADCVI IKGTQVYDSK
     651  KGGFIDLGIS DVIQIFGRGG RPGFGSANGT GILCTSNDRL DHYVSLITQQ
     701  HPIESRFGSK LVDNLNAEIS LGSVTNVDEA IEWLGYTYMF VRMRKNPFTY
     751  GIDWEEIAND PQLYERRRKM IVVAARRLHA LQMIVFDEVS MHFIAKDLGR
     801  VSSDFYLLNE SVEIFNQMCD PRATEADVLS MISMSSEFDG IKFREEESKE
     851  LKRLSDESVE CQIGSQLDTP QGKANVLLQA YISQTRIFDS ALSSDSNYVA
     901  QNSVRICRAL FLIGVNRRWG KFSNVMLNIC KSIEKRLWAF DHPLCQFDLP
     951  ENIIRRIRDT KPSMEHLLEL EADELGELVH NKKAGSRLYK ILSRFPKINI
    1001  EAEIFPITTN VMRIHIALGP DFVWDSRIHG DAQFFWVFVE ESDKSQILHF
    1051  EKFILNRRQL NNQHEMDFMI PLSDPLPPQV VVKVVSDTWI GCESTHAISF
    1101  QHLIRPFNET LQTKLLKLRP LPTSALQNPL IESIYPFKYF NPMQTMTFYT
    1151  LYNTNENAFV GSPTGSGKTI VAELAIWHAF KTFPGKKIVY IAPMKALVRE
    1201  RVDDWRKKIT PVTGDKVVEL TGDSLPDPKD VHDATIVITT PEKFDGISRN
    1251  WQTRKFVQDV SLIIMDEIHL LASDRGPILE MIVSRMNYIS SQTKQPVRLL
    1301  GMSTAVSNAY DMAGWLGVKD HGLYNFPSSV RPVPLKMYID GFPDNLAFCP
    1351  LMKTMNKPVF MAIKQHSPDK PALIFVASRR QTRLTALDLI HLCGMEDNPR
    1401  RFLNIDDEEE LQYYLSQVTD DTLKLSLQFG IGLHHAGLVQ KDRSISHQLF
    1451  QKNKIQILIA TSTLAWGVNL PAHLVIIKGT QFFDAKIEGY RDMDLTDILQ
    1501  MMGRAGRPAY DTTGTAIVYT KESKKMFYKH FLNVGFPVES SLHKVLDDHL
    1551  GAEITSGSIT NKQEALDFLS WTFLFRRAHH NPTYYGIEDD TSTAGVSEHL
    1601  SSLIDSTLEN LRESQCVLLH GDDIVATPFL SISSYYYISH LTIRQLLKQI
    1651  HDHATFQEVL RWLSLAVEYN ELPVRGGEII MNEEMSQQSR YSVESTFTDE
    1701  FELPMWDPHV KTFLLLQAHL SRVDLPIADY IQDTVSVLDQ SLRILQAYID
    1751  VASELGYFHT VLTMIKMMQC IKQGYWYEDD PVSVLPGLQL RRIKDYTFSE
    1801  QGFIEMTPQQ KKKKLLTLEE IGRFGYKKLL NVFDQLTFGM TESEDTKKRF
    1851  VSVCQRLPVL EGMKFEEQEN NEVLTFYSKH LSSKHNNGFE VYCDKFPKIQ
    1901  KELWFLIGHK GDELLMIKRC QPKQMNKEVI IHCDLFIPEE IRGEELQFSL
    1951  INDALGLRYD MVHKLIS*

external links for Slh1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Slh1p
1) Searfoss AM and Wickner RB  (2000) 3' poly(A) is dispensable for translation. Proc Natl Acad Sci U S A 97(16):9133-7
2) Searfoss A, et al.  (2001) Linking the 3' poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p. Mol Cell Biol 21(15):4900-8
3) de la Cruz J, et al.  (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41