APL6/YGR261C Protein Information Help

Standard Name Apl6p 1
Systematic Name Ygr261cp
Alias Yks5p 2
ORF Classification Verified
Description Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools (1, 2)
Name Description clathrin Adaptor Protein complex Large chain 1
Experimental Data
Molecules/cell 3570 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 809
Molecular Weight (Da) 91,606
Isoelectric Point (pI) 5.66

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Apl6p (InterPro)
Physical Interactions There are 39 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530A8 | P46682
MIPS: YGR261C
NCBI: 1017729 | 1323475 | 1536953 | 1703169 | 398366337 | NP_011777.3
GenBank/EMBL/DDBJ: DAA08351.1 | U35411 | Y07777 | Z73046
Amino Acid Sequence (or in FASTA format)
 
       1  MVDSIHRIAS ALDTAKVITR EAAAVATSKL GESSYTYYSQ NINPQQLVTL
      51  LNSRNSREVR DAMKRIISIM ASDDDSIDVQ LYFADVVKNI TTNDTKVKRL
     101  IHLYLLRFAE NDPNLTLLSI NSLQKSLSDS NSELRCFALS ALSDMKMSSL
     151  APIILHTVKK LVTDPSAMVR GEVALAIIKL YRAGKNDYHE ELLDILKELM
     201  ADTDPKVISC AVLAYKECYA DHLELLHGHF RRYCRIIKQL DSWSQSYLIE
     251  LLIKYCKQYL PKPTVVDKSS EGSPRSCPLP DKYNEIEYPS YEVVNDPDLD
     301  LFLQSLNCLI YSSNPTVILS CCNALYQLAS PLQMKNTKFI EALVRTVTMT
     351  ENQGNKEMLL QAIHFLSILD QTLFLPYTKK FYVFPKDPIV ASIWKIQILS
     401  TLINESNVKE IFKELKYYVA SAHFPENVVI MAVKSLSRCG QLSTSWESHV
     451  MKWLIDHMES HNLSASVLDA YVNVIRMLVQ KNPTKHLRII FKLADLLTVQ
     501  TSLADNARAG IVWLFGEIAS IEFKICPDVL RRLIQNFSNE GPETRCQILV
     551  LSAKLLSYDI DNFKQAQVTG SEENNQNPPY YDFSGSRISQ MYNAVLYLAK
     601  YDDEFDIRDR ARMISSLFDS GKYEIVSLLL QAPKPTARSD DFIVSARLET
     651  HTPEIKEFFR MLPWNTEITE VGETGNDIRE GAELKDYNKY KKSFSSQSFI
     701  TNNSARSFTS SSNAKLTGIN DGDSNSISGK GNVNTFTSQN GKKYRLQSLD
     751  EFFSDIPERK SKPRKIIKVV EESSDEDEDE SEESSDDDEY SDSSLGTSSS
     801  GTSSSHLEL*

external links for Apl6p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Apl6p
1) Cowles CR, et al.  (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91(1):109-18
2) Panek HR, et al.  (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41