TNA1/YGR260W Protein Information

Standard Name	Tna1p 1
Systematic Name	Ygr260wp
ORF Classification	Verified
Description	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) (1, 2)
Name Description	Transporter of Nicotinic Acid 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	534
Molecular Weight (Da)	60,134
Isoelectric Point (pI)	6.8

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tna1p (InterPro)
Transmembrane Domains	There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 41 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000137094 \| P53322 MIPS: YGR260W NCBI: 1323473 \| 1536952 \| 1723769 \| 6321698 \| NP_011776.1 GenBank/EMBL/DDBJ: DAA08350.1 \| Y07777 \| Z73044
External Classifications	TC: 2.A.1.14 [The Anion: Cation Symporter (ACS) Family]

Amino Acid Sequence (or in FASTA format)
1 MSNKFTMESP KHLVDDVLFI SPTNDGSEEK PTEVTFQEDE GHDASLHNRS 51 HDKKSELATE REIMATTTDD DGIPSPSHPM EKRVLRKMDI YLIPLMGMLY 101 FLSNLDKSNI GNAEVAGLSK DIHLVGTQYN TCVTVFFATY VLFDPIGTNL 151 LKIMGPPLMM SICLTCFGAI SLGTAWVKNY AQLIVVRLLL GAFEGMIYPA 201 INMYLSVCYR REQYALRFAF VFSAACLSSS FGGLIAYGCS KISGSLKDWQ 251 YIYIVEGCIS LGFVPFYAFG LSKNLEDSWF FNKEEKEYIS ERYKTMNTFD 301 PDEKFEWFQV WQAVKDVKTW ASAVALFGID LTTFGLTVFL PIIITSMGFT 351 NVRAQLMTVP IYFLTAIVFF ICAVWSDRIK LRSPFILGAC LTTSIGIAIV 401 LGSQVHGVRY FGVYILCMGI YVNAACNCLW LSGNTGNYFK RATALGINLF 451 FGSGSGLVSG QIFVAKDKPR YIKGLSISLA FQVFSIFMTV VQIFLYKREN 501 DKKKAIIDRC NELGEPIPYD ERLSDKNPEF KYMY*

Amino Acid Sequence (or in FASTA format)

       1  MSNKFTMESP KHLVDDVLFI SPTNDGSEEK PTEVTFQEDE GHDASLHNRS
      51  HDKKSELATE REIMATTTDD DGIPSPSHPM EKRVLRKMDI YLIPLMGMLY
     101  FLSNLDKSNI GNAEVAGLSK DIHLVGTQYN TCVTVFFATY VLFDPIGTNL
     151  LKIMGPPLMM SICLTCFGAI SLGTAWVKNY AQLIVVRLLL GAFEGMIYPA
     201  INMYLSVCYR REQYALRFAF VFSAACLSSS FGGLIAYGCS KISGSLKDWQ
     251  YIYIVEGCIS LGFVPFYAFG LSKNLEDSWF FNKEEKEYIS ERYKTMNTFD
     301  PDEKFEWFQV WQAVKDVKTW ASAVALFGID LTTFGLTVFL PIIITSMGFT
     351  NVRAQLMTVP IYFLTAIVFF ICAVWSDRIK LRSPFILGAC LTTSIGIAIV
     401  LGSQVHGVRY FGVYILCMGI YVNAACNCLW LSGNTGNYFK RATALGINLF
     451  FGSGSGLVSG QIFVAKDKPR YIKGLSISLA FQVFSIFMTV VQIFLYKREN
     501  DKKKAIIDRC NELGEPIPYD ERLSDKNPEF KYMY*

external links for Tna1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
YGOB	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YOGY	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Tna1p

1)	Llorente B and Dujon B (2000) Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w). FEBS Lett 475(3):237-41
2)	Klebl F, et al. (2000) Transcription of the yeast TNA1 gene is not only regulated by nicotinate but also by p-aminobenzoate. FEBS Lett 481(1):86-7