GND2/YGR256W Protein Information Help

Standard Name Gnd2p
Systematic Name Ygr256wp
ORF Classification Verified
Description 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication (1)
Experimental Data
Molecules/cell 556 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 492
Molecular Weight (Da) 53,922
Isoelectric Point (pI) 7.28

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gnd2p (InterPro)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000124F5F | P53319
MIPS: YGR256W
NCBI: 1323466 | 1502359 | 1703016 | 398366323 | 51013073 | NP_011772.3 | NM_001181385.3
GenBank/EMBL/DDBJ: AAT92830.1 | CAA67612.1 | CAA97285.1 | DAA08347.1 | AY692811 | X99228 | Z73041
External Classifications EC: 1.1.1.44 [Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)]
Amino Acid Sequence (or in FASTA format)
       1  MSKAVGDLGL VGLAVMGQNL ILNAADHGFT VVAYNRTQSK VDRFLANEAK
      51  GKSIIGATSI EDLVAKLKKP RKIMLLIKAG APVDTLIKEL VPHLDKGDII
     101  IDGGNSHFPD TNRRYEELTK QGILFVGSGV SGGEDGARFG PSLMPGGSAE
     151  AWPHIKNIFQ SIAAKSNGEP CCEWVGPAGS GHYVKMVHNG IEYGDMQLIC
     201  EAYDIMKRIG RFTDKEISEV FDKWNTGVLD SFLIEITRDI LKFDDVDGKP
     251  LVEKIMDTAG QKGTGKWTAI NALDLGMPVT LIGEAVFARC LSAIKDERKR
     301  ASKLLAGPTV PKDAIHDREQ FVYDLEQALY ASKIISYAQG FMLIREAARS
     351  YGWKLNNPAI ALMWRGGCII RSVFLAEITK AYRDDPDLEN LLFNEFFASA
     401  VTKAQSGWRR TIALAATYGI PTPAFSTALA FYDGYRSERL PANLLQAQRD
     451  YFGAHTFRIL PECASAHLPV DKDIHINWTG HGGNISSSTY QA*       

external links for Gnd2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Aspergillus (AspGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Gnd2p
1) Sinha A and Maitra PK  (1992) Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone in Saccharomyces cerevisiae. J Gen Microbiol 138(9):1865-73
2) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41