GND2/YGR256W Protein Information

Standard Name	Gnd2p
Systematic Name	Ygr256wp
ORF Classification	Verified
Description	6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication (1)

Experimental Data
Molecules/cell	556 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	492
Molecular Weight (Da)	53,922
Isoelectric Point (pI)	7.28

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gnd2p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000124F5F \| P53319 MIPS: YGR256W NCBI: 1323466 \| 1502359 \| 1703016 \| 398366323 \| 51013073 \| NP_011772.3 GenBank/EMBL/DDBJ: DAA08347.1 \| AY692811 \| X99228 \| Z73041
External Classifications	EC: 1.1.1.44 [Phosphogluconate dehydrogenase (decarboxylating)]

Amino Acid Sequence (or in FASTA format)
1 MSKAVGDLGL VGLAVMGQNL ILNAADHGFT VVAYNRTQSK VDRFLANEAK 51 GKSIIGATSI EDLVAKLKKP RKIMLLIKAG APVDTLIKEL VPHLDKGDII 101 IDGGNSHFPD TNRRYEELTK QGILFVGSGV SGGEDGARFG PSLMPGGSAE 151 AWPHIKNIFQ SIAAKSNGEP CCEWVGPAGS GHYVKMVHNG IEYGDMQLIC 201 EAYDIMKRIG RFTDKEISEV FDKWNTGVLD SFLIEITRDI LKFDDVDGKP 251 LVEKIMDTAG QKGTGKWTAI NALDLGMPVT LIGEAVFARC LSAIKDERKR 301 ASKLLAGPTV PKDAIHDREQ FVYDLEQALY ASKIISYAQG FMLIREAARS 351 YGWKLNNPAI ALMWRGGCII RSVFLAEITK AYRDDPDLEN LLFNEFFASA 401 VTKAQSGWRR TIALAATYGI PTPAFSTALA FYDGYRSERL PANLLQAQRD 451 YFGAHTFRIL PECASAHLPV DKDIHINWTG HGGNISSSTY QA*

Amino Acid Sequence (or in FASTA format)

       1  MSKAVGDLGL VGLAVMGQNL ILNAADHGFT VVAYNRTQSK VDRFLANEAK
      51  GKSIIGATSI EDLVAKLKKP RKIMLLIKAG APVDTLIKEL VPHLDKGDII
     101  IDGGNSHFPD TNRRYEELTK QGILFVGSGV SGGEDGARFG PSLMPGGSAE
     151  AWPHIKNIFQ SIAAKSNGEP CCEWVGPAGS GHYVKMVHNG IEYGDMQLIC
     201  EAYDIMKRIG RFTDKEISEV FDKWNTGVLD SFLIEITRDI LKFDDVDGKP
     251  LVEKIMDTAG QKGTGKWTAI NALDLGMPVT LIGEAVFARC LSAIKDERKR
     301  ASKLLAGPTV PKDAIHDREQ FVYDLEQALY ASKIISYAQG FMLIREAARS
     351  YGWKLNNPAI ALMWRGGCII RSVFLAEITK AYRDDPDLEN LLFNEFFASA
     401  VTKAQSGWRR TIALAATYGI PTPAFSTALA FYDGYRSERL PANLLQAQRD
     451  YFGAHTFRIL PECASAHLPV DKDIHINWTG HGGNISSSTY QA*

external links for Gnd2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Gnd2p

1)	Sinha A and Maitra PK (1992) Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone in Saccharomyces cerevisiae. J Gen Microbiol 138(9):1865-73
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41