SOL4/YGR248W Protein Information

Standard Name	Sol4p 1
Systematic Name	Ygr248wp
ORF Classification	Verified
Description	6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication (1, 2, 3)
Name Description	Suppressor Of Los1-1 1

Experimental Data
Molecules/cell	4320 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	255
Molecular Weight (Da)	28,447
Isoelectric Point (pI)	5.11

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sol4p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000135C7C \| P53315 MIPS: YGR248W NCBI: 1323450 \| 1723763 \| 398366293 \| NP_011764.3 GenBank/EMBL/DDBJ: DAA08339.1 \| Z73033
External Classifications	EC: 3.1.1.31 [6-phosphogluconolactonase]

Amino Acid Sequence (or in FASTA format)
1 MVKLQRFSEK KSLIHEFGKF ILEKQESALT GDADAVFNIA ISGGSMNQAL 51 YESLVNDKNI FPHIKWPQWR IFFCDERLVP FEDPQSNYGQ FKKTVLDPLV 101 HQGNQLNLGP TVYTINESLI GGGETANRKI AEEYASMLPA SFDLILLGCG 151 EDGHTCSLFP GVEFNYLVEE MDRKVLWCNN SPKAPKDRIT FTLAVVAEAK 201 SVCFLVRGAA KKAIMHDVLI VKNSELPSVL VNEMVGTKVT WFLDDEAGAL 251 IPENC*

Amino Acid Sequence (or in FASTA format)

       1  MVKLQRFSEK KSLIHEFGKF ILEKQESALT GDADAVFNIA ISGGSMNQAL
      51  YESLVNDKNI FPHIKWPQWR IFFCDERLVP FEDPQSNYGQ FKKTVLDPLV
     101  HQGNQLNLGP TVYTINESLI GGGETANRKI AEEYASMLPA SFDLILLGCG
     151  EDGHTCSLFP GVEFNYLVEE MDRKVLWCNN SPKAPKDRIT FTLAVVAEAK
     201  SVCFLVRGAA KKAIMHDVLI VKNSELPSVL VNEMVGTKVT WFLDDEAGAL
     251  IPENC*

external links for Sol4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Sol4p

1)	Stanford DR, et al. (2004) Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism. Genetics 168(1):117-27
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41