SDA1/YGR245C Protein Information Help

Standard Name Sda1p
Systematic Name Ygr245cp
ORF Classification Verified
Description Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis (1, 2, 3)
Name Description Severe Depolymerization of Actin 1
Experimental Data
Molecules/cell 3640 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 767
Molecular Weight (Da) 86,618
Isoelectric Point (pI) 6.92

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sda1p (InterPro)
Physical Interactions There are 146 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000005321E | P53313
MIPS: YGR245C
NCBI: 1323444 | 1702955 | 1723761 | 398366281 | NP_011761.3
GenBank/EMBL/DDBJ: DAA08336.1 | Y07703 | Z73030
Amino Acid Sequence (or in FASTA format)
 
       1  MGRRSRAAML PTNIILLQNL VKRDPESYQE EFLQQYAHYE SLRDIFMLNG
      51  LAGGDSAAAT NGLDVGNGSS TMAGTNGTTM STSTSQLIEL VGFVSQVCSC
     101  FPRETANFPS ELKQLLLEHH KSLPFELKEK ILSCLTMLRN KDVITAEELI
     151  QSLFPLLVAY SSHGNSLGVN SHAKELRKII YTNLISLLKS CNTNGKNQKL
     201  NKSTQAVCFN LLDQPDSQGI WATKLTRELW RRGIWDDSRT VEIMTQAALH
     251  QDVKIVMSGV MFFLDADRER EENFEENSED EDGFDLDALR HKMQVNKKTG
     301  RRGKKLENAI KTVKKKKKNG PGAPQGYLNF SAIHLLRDPQ GFAEKLFKEH
     351  LSGKTKNKFD MEQKISLMQL LSRLIGTHKL IVLGIYTFFL KYLTPKQRDV
     401  TRIMSACAQA CHDLVPPEVI NVMVRKIADE FVSDGVANEV AAAGINTIRE
     451  ICSRAPLAID EILLQDLVEY KGSKAKGVNM AAKSLIALYR DVAPEMLKKK
     501  DRGKNAAMEV QEAKKGGKDS KRPQFGADNS VQGIAGIELL AKWKKEHGEE
     551  SENEDADANW EVDVDSEEDD VDGEWVTMDS DKEYDVDMED SDDEKDNAKG
     601  KESDSDLELS DDDDEKEVKD EQEDADIDPE AAFREIASTR ILTPADFAKL
     651  QELRNEESVA KIMGIHKQDK REELVDASTL TGPIKYKQSR EERLQKVLEG
     701  REGRDKFGSR RGKRDNMRST TNREKERRKN FVMSIHKRSV RGKQKMSLRD
     751  KQKVLRAHIT KQKKKGY*

external links for Sda1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sda1p
1) Buscemi G, et al.  (2000) The Saccharomyces cerevisiae SDA1 gene is required for actin cytoskeleton organization and cell cycle progression. J Cell Sci 113 ( Pt 7)():1199-211
2) Zimmerman ZA and Kellogg DR  (2001) The Sda1 protein is required for passage through start. Mol Biol Cell 12(1):201-19
3) Babbio F, et al.  (2004) Expression and localization studies of hSDA, the human ortholog of the yeast SDA1 gene. Cell Cycle 3(4):486-90
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41