HSV2/YGR223C Protein Information

Standard Name	Hsv2p 1
Systematic Name	Ygr223cp
ORF Classification	Verified
Description	Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization (1, 2, 3)
Name Description	Homologous with SVP1 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	448
Molecular Weight (Da)	51,235
Isoelectric Point (pI)	9.76

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hsv2p (InterPro)
Physical Interactions	There are 18 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AFA6 \| P50079 MIPS: YGR223C NCBI: 1323402 \| 1723745 \| 6321662 \| 886915 \| NP_011739.1 GenBank/EMBL/DDBJ: DAA08316.1 \| X87941 \| Z73008

Amino Acid Sequence (or in FASTA format)
1 MDVRRPIREA VNNRRKPKFL SVSFNQDDSC FSVALENGFR IFNTDPLTSK 51 LSKTFKESAT NQSRGTGIGY TRMLYRTNYI ALVGGGKRPR HALNKLIIWD 101 DLLQKETITL KFMSSIKDVF LSRIHIVVVL ENTIEIFQFQ TNPQRICPIL 151 DIPPNGSVDY VVCSSKHLQS QASQSQSKIL EIIAFPSNKC VGQIQVADLS 201 QIKYNSQNPK ESALLPTSII KAHKNPIKLV RLNRQGTMVA TCSVQGTLIR 251 IFSTHNGTLI KEFRRGVDKA DIYEMSFSPN GSKLAVLSNK QTLHIFQIFE 301 TTNTETNTPD HSRANGSSHP LKNYIPKGLW RPKYLDSVWS ICNAHLKNPI 351 FDAHRNDNSG DVTHDNEFYK DRCRIGWCQD SNNREQDDSL VLVWQNSGIW 401 EKFVILEKEQ QDSSKTHYSL NESLRNEDTK SAGEPTRWEL VRESWREL*

Amino Acid Sequence (or in FASTA format)

       1  MDVRRPIREA VNNRRKPKFL SVSFNQDDSC FSVALENGFR IFNTDPLTSK
      51  LSKTFKESAT NQSRGTGIGY TRMLYRTNYI ALVGGGKRPR HALNKLIIWD
     101  DLLQKETITL KFMSSIKDVF LSRIHIVVVL ENTIEIFQFQ TNPQRICPIL
     151  DIPPNGSVDY VVCSSKHLQS QASQSQSKIL EIIAFPSNKC VGQIQVADLS
     201  QIKYNSQNPK ESALLPTSII KAHKNPIKLV RLNRQGTMVA TCSVQGTLIR
     251  IFSTHNGTLI KEFRRGVDKA DIYEMSFSPN GSKLAVLSNK QTLHIFQIFE
     301  TTNTETNTPD HSRANGSSHP LKNYIPKGLW RPKYLDSVWS ICNAHLKNPI
     351  FDAHRNDNSG DVTHDNEFYK DRCRIGWCQD SNNREQDDSL VLVWQNSGIW
     401  EKFVILEKEQ QDSSKTHYSL NESLRNEDTK SAGEPTRWEL VRESWREL*

external links for Hsv2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Hsv2p

1)	Dove SK, et al. (2004) Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J 23(9):1922-33
2)	Krick R, et al. (2008) Dissecting the localization and function of Atg18, Atg21 and Ygr223c. Autophagy 4(7):896-910
3)	Baskaran S, et al. (2012) Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell 47(3):339-48