CRM1/YGR218W Protein Information Help

Standard Name Crm1p 1
Systematic Name Ygr218wp
Alias Kap124p , Xpo1p
ORF Classification Verified
Description Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin (2, 3)
Name Description Chromosome Region Maintenance 1
Experimental Data
Molecules/cell 7080 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,084
Molecular Weight (Da) 124,103
Isoelectric Point (pI) 5.24

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Crm1p (InterPro)
Physical Interactions There are 156 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052E89 | P30822
MIPS: YGR218W
NCBI: 1323393 | 287601 | 297343065 | 398366207 | 399300 | 403072302 | 409107319 | 428698054 | 440690976 | 440690979 | 440690983 | 440690987 | 440690989 | 440690995 | 440690999 | 440691003 | 440691007 | 440691011 | 440691015 | 886910 | NP_011734.3
GenBank/EMBL/DDBJ: DAA08312.1 | D13039 | X87941 | Z73003
Amino Acid Sequence (or in FASTA format)
 
       1  MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK
      51  ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS
     101  MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN
     151  VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV
     201  LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA
     251  ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT
     301  YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL
     351  SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST
     401  GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE
     451  IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW
     501  SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV
     551  VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI
     601  KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI
     651  IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA
     701  NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA
     751  TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM
     801  NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT
     851  EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV
     901  EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS
     951  GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS
    1001  NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL
    1051  FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD*

external links for Crm1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Crm1p
1) Toda T, et al.  (1992) Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1. Mol Cell Biol 12(12):5474-84
2) Maurer P, et al.  (2001) The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Mol Biol Cell 12(3):539-49
3) Johnson AW, et al.  (2002) Nuclear export of ribosomal subunits. Trends Biochem Sci 27(11):580-5
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41