TRX2/YGR209C Protein Information Help

Standard Name Trx2p
Systematic Name Ygr209cp
Alias Lma1p 1
ORF Classification Verified
Description Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8, 9)
Name Description ThioRedoXin
Experimental Data
Molecules/cell 17200 10
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 104
Molecular Weight (Da) 11,204
Isoelectric Point (pI) 4.62

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Trx2p (InterPro)
Physical Interactions There are 35 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F91C | P22803
MIPS: YGR209C
NCBI: 1165214 | 122920148 | 122920149 | 1323375 | 135743 | 145579547 | 173026 | 173050 | 323714537 | 383875712 | 398366149 | 45269525 | 790500 | NP_011725.3
GenBank/EMBL/DDBJ: DAA08303.1 | AY557817 | M59168 | M62648 | U40843 | Z49133 | Z72994
Amino Acid Sequence (or in FASTA format)
 
       1  MVTQLKSASE YDSALASGDK LVVVDFFATW CGPCKMIAPM IEKFAEQYSD
      51  AAFYKLDVDE VSDVAQKAEV SSMPTLIFYK GGKEVTRVVG ANPAAIKQAI
     101  ASNV*

external links for Trx2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Trx2p
1) Xu Z and Wickner W  (1996) Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae. J Cell Biol 132(5):787-94
2) Pedrajas JR, et al.  (1999) Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae. J Biol Chem 274(10):6366-73
3) Xu Z, et al.  (1997) A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance. J Cell Biol 136(2):299-306
4) Barlowe C  (1997) Coupled ER to Golgi transport reconstituted with purified cytosolic proteins. J Cell Biol 139(5):1097-108
5) Spang A and Schekman R  (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol 143(3):589-99
6) Garrido EO and Grant CM  (2002) Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides. Mol Microbiol 43(4):993-1003
7) Trotter EW and Grant CM  (2002) Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae. Mol Microbiol 46(3):869-78
8) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
9) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
10) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41