CIR1/YGR207C Protein Information

Standard Name	Cir1p 1
Systematic Name	Ygr207cp
ORF Classification	Verified
Description	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response (1, 2, 3)
Name Description	Changed Intracellular Redox state 1

Experimental Data
Molecules/cell	2400 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	261
Molecular Weight (Da)	28,758
Isoelectric Point (pI)	8.71

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cir1p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012A251 \| P42940 MIPS: YGR207C NCBI: 1169560 \| 1323371 \| 45270646 \| 6321646 \| 790498 \| NP_011723.1 GenBank/EMBL/DDBJ: DAA08301.1 \| AY558378 \| Z49133 \| Z72992

Amino Acid Sequence (or in FASTA format)
1 MSAKQQLRIL VPVKRVVDFQ IKPRVNKTLT GIETSGIKFS INPFDDIAVE 51 EAIRIKEKNK SLVESTHAVS IGSAKAQDIL RNCLAKGIDT CSLIDSVGKE 101 NIEPLAIAKI LKAVVEKKGS NLVLMGKQAI DDDCNNTGQM LAGLLNWPQA 151 TNAAKVEFLD NGRVQVTREI DDGEEVIEAS LPMVITTDLR LNTPRYVGLP 201 KLMKAKKKPI EKLDIAKDFP EINIEPQLKI VSMEEPKTKS PGVKLNSVDE 251 LIEKLKEVKA I*

Amino Acid Sequence (or in FASTA format)

       1  MSAKQQLRIL VPVKRVVDFQ IKPRVNKTLT GIETSGIKFS INPFDDIAVE
      51  EAIRIKEKNK SLVESTHAVS IGSAKAQDIL RNCLAKGIDT CSLIDSVGKE
     101  NIEPLAIAKI LKAVVEKKGS NLVLMGKQAI DDDCNNTGQM LAGLLNWPQA
     151  TNAAKVEFLD NGRVQVTREI DDGEEVIEAS LPMVITTDLR LNTPRYVGLP
     201  KLMKAKKKPI EKLDIAKDFP EINIEPQLKI VSMEEPKTKS PGVKLNSVDE
     251  LIEKLKEVKA I*

external links for Cir1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Cir1p

1)	Lopes J, et al. (2010) The Saccharomyces cerevisiae Genes, AIM45, YGR207c/CIR1 and YOR356w/CIR2, Are Involved in Cellular Redox State Under Stress Conditions. Open Microbiol J 4():75-82
2)	Gonzalez-Cabo P, et al. (2005) Frataxin interacts functionally with mitochondrial electron transport chain proteins. Hum Mol Genet 14(15):2091-8
3)	Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41