CIR1/YGR207C Protein Information Help

Standard Name Cir1p 1
Systematic Name Ygr207cp
ORF Classification Verified
Description Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response (1, 2, 3)
Name Description Changed Intracellular Redox state 1
Experimental Data
Molecules/cell 2400 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 261
Molecular Weight (Da) 28,758
Isoelectric Point (pI) 8.71

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cir1p (InterPro)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012A251 | P42940
MIPS: YGR207C
NCBI: 1169560 | 1323371 | 45270646 | 6321646 | 790498 | NP_011723.1 | NM_001181336.1
GenBank/EMBL/DDBJ: AAS56704.1 | CAA89000.1 | CAA97234.1 | DAA08301.1 | AY558378 | Z49133 | Z72992
Amino Acid Sequence (or in FASTA format)
       1  MSAKQQLRIL VPVKRVVDFQ IKPRVNKTLT GIETSGIKFS INPFDDIAVE
      51  EAIRIKEKNK SLVESTHAVS IGSAKAQDIL RNCLAKGIDT CSLIDSVGKE
     101  NIEPLAIAKI LKAVVEKKGS NLVLMGKQAI DDDCNNTGQM LAGLLNWPQA
     151  TNAAKVEFLD NGRVQVTREI DDGEEVIEAS LPMVITTDLR LNTPRYVGLP
     201  KLMKAKKKPI EKLDIAKDFP EINIEPQLKI VSMEEPKTKS PGVKLNSVDE
     251  LIEKLKEVKA I*                                         

external links for Cir1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA


IMP


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Cir1p
1) Lopes J, et al.  (2010) The Saccharomyces cerevisiae Genes, AIM45, YGR207c/CIR1 and YOR356w/CIR2, Are Involved in Cellular Redox State Under Stress Conditions. Open Microbiol J 4():75-82
2) Gonzalez-Cabo P, et al.  (2005) Frataxin interacts functionally with mitochondrial electron transport chain proteins. Hum Mol Genet 14(15):2091-8
3) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41