TDA10/YGR205W Protein Information

Standard Name	Tda10p 1
Systematic Name	Ygr205wp
ORF Classification	Verified
Description	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele (1, 2)
Name Description	Topoisomerase I Damage Affected 1

Experimental Data
Molecules/cell	4280 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	290
Molecular Weight (Da)	33,337
Isoelectric Point (pI)	5.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tda10p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AFA0 \| P42938 MIPS: YGR205W NCBI: 1176053 \| 1323367 \| 398366141 \| 40889194 \| 45270436 \| 790496 \| 806320 \| NP_011721.3 GenBank/EMBL/DDBJ: DAA08299.1 \| AY558273 \| M12878 \| Z49133 \| Z72990
External Classifications	EC: 2.7.-.- [Transferases transferring phosphorous-containing groups]

Amino Acid Sequence (or in FASTA format)
1 MCDKSKTVLD YTIEFLDKYI PEWFETGNKC PLFIFFSGPQ GSGKSFTSIQ 51 IYNHLMEKYG GEKSIGYASI DDFYLTHEDQ LKLNEQFKNN KLLQGRGLPG 101 THDMKLLQEV LNTIFNNNEH PDQDTVVLPK YDKSQFKGEG DRCPTGQKIK 151 LPVDIFILEG WFLGFNPILQ GIENNDLLTG DMVDVNAKLF FYSDLLWRNP 201 EIKSLGIVFT TDNINNVYGW RLQQEHELIS KVGKGMTDEQ VHAFVDRYMP 251 SYKLYLNDFV RSESLGSIAT LTLGIDSNRN VYSTKTRCIE *

Amino Acid Sequence (or in FASTA format)

       1  MCDKSKTVLD YTIEFLDKYI PEWFETGNKC PLFIFFSGPQ GSGKSFTSIQ
      51  IYNHLMEKYG GEKSIGYASI DDFYLTHEDQ LKLNEQFKNN KLLQGRGLPG
     101  THDMKLLQEV LNTIFNNNEH PDQDTVVLPK YDKSQFKGEG DRCPTGQKIK
     151  LPVDIFILEG WFLGFNPILQ GIENNDLLTG DMVDVNAKLF FYSDLLWRNP
     201  EIKSLGIVFT TDNINNVYGW RLQQEHELIS KVGKGMTDEQ VHAFVDRYMP
     251  SYKLYLNDFV RSESLGSIAT LTLGIDSNRN VYSTKTRCIE *

external links for Tda10p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Tda10p

1)	Reid RJ, et al. (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86
2)	de La Sierra-Gallay IL, et al. (2004) Crystal structure of the YGR205w protein from Saccharomyces cerevisiae: close structural resemblance to E. coli pantothenate kinase. Proteins 54(4):776-83
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41