XKS1/YGR194C Protein Information

Standard Name	Xks1p 1
Systematic Name	Ygr194cp
ORF Classification	Verified
Description	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains (1, 2, 3)
Name Description	XyluloKinaSe 1

Experimental Data
Molecules/cell	3460 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	600
Molecular Weight (Da)	68,320
Isoelectric Point (pI)	6.8

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Xks1p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000530CD \| P42826 MIPS: YGR194C NCBI: 1323345 \| 1723736 \| 398366095 \| 755799 \| NP_011710.3 GenBank/EMBL/DDBJ: DAA08287.1 \| X82408 \| Z72979
External Classifications	EC: 2.7.1.17 [Xylulokinase]

Amino Acid Sequence (or in FASTA format)
1 MLCSVIQRQT REVSNTMSLD SYYLGFDLST QQLKCLAINQ DLKIVHSETV 51 EFEKDLPHYH TKKGVYIHGD TIECPVAMWL EALDLVLSKY REAKFPLNKV 101 MAVSGSCQQH GSVYWSSQAE SLLEQLNKKP EKDLLHYVSS VAFARQTAPN 151 WQDHSTAKQC QEFEECIGGP EKMAQLTGSR AHFRFTGPQI LKIAQLEPEA 201 YEKTKTISLV SNFLTSILVG HLVELEEADA CGMNLYDIRE RKFSDELLHL 251 IDSSSKDKTI RQKLMRAPMK NLIAGTICKY FIEKYGFNTN CKVSPMTGDN 301 LATICSLPLR KNDVLVSLGT STTVLLVTDK YHPSPNYHLF IHPTLPNHYM 351 GMICYCNGSL ARERIRDELN KERENNYEKT NDWTLFNQAV LDDSESSENE 401 LGVYFPLGEI VPSVKAINKR VIFNPKTGMI EREVAKFKDK RHDAKNIVES 451 QALSCRVRIS PLLSDSNASS QQRLNEDTIV KFDYDESPLR DYLNKRPERT 501 FFVGGASKND AIVKKFAQVI GATKGNFRLE TPNSCALGGC YKAMWSLLYD 551 SNKIAVPFDK FLNDNFPWHV MESISDVDNE NWDRYNSKIV PLSELEKTLI 601 *

Amino Acid Sequence (or in FASTA format)

       1  MLCSVIQRQT REVSNTMSLD SYYLGFDLST QQLKCLAINQ DLKIVHSETV
      51  EFEKDLPHYH TKKGVYIHGD TIECPVAMWL EALDLVLSKY REAKFPLNKV
     101  MAVSGSCQQH GSVYWSSQAE SLLEQLNKKP EKDLLHYVSS VAFARQTAPN
     151  WQDHSTAKQC QEFEECIGGP EKMAQLTGSR AHFRFTGPQI LKIAQLEPEA
     201  YEKTKTISLV SNFLTSILVG HLVELEEADA CGMNLYDIRE RKFSDELLHL
     251  IDSSSKDKTI RQKLMRAPMK NLIAGTICKY FIEKYGFNTN CKVSPMTGDN
     301  LATICSLPLR KNDVLVSLGT STTVLLVTDK YHPSPNYHLF IHPTLPNHYM
     351  GMICYCNGSL ARERIRDELN KERENNYEKT NDWTLFNQAV LDDSESSENE
     401  LGVYFPLGEI VPSVKAINKR VIFNPKTGMI EREVAKFKDK RHDAKNIVES
     451  QALSCRVRIS PLLSDSNASS QQRLNEDTIV KFDYDESPLR DYLNKRPERT
     501  FFVGGASKND AIVKKFAQVI GATKGNFRLE TPNSCALGGC YKAMWSLLYD
     551  SNKIAVPFDK FLNDNFPWHV MESISDVDNE NWDRYNSKIV PLSELEKTLI
     601  *

external links for Xks1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Xks1p

1)	Rodriguez-Pena JM, et al. (1998) The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae. FEMS Microbiol Lett 162(1):155-60
2)	Richard P, et al. (2000) The role of xylulokinase in Saccharomyces cerevisiae xylulose catabolism. FEMS Microbiol Lett 190(1):39-43
3)	Jin YS, et al. (2003) Optimal growth and ethanol production from xylose by recombinant Saccharomyces cerevisiae require moderate D-xylulokinase activity. Appl Environ Microbiol 69(1):495-503
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41