HGH1/YGR187C Protein Information

Standard Name	Hgh1p 1
Systematic Name	Ygr187cp
ORF Classification	Verified
Description	Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress (2, 3, 4, 5, 6)
Name Description	HmG1/2 Homolog 1

Experimental Data
Molecules/cell	20800 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	394
Molecular Weight (Da)	44,951
Isoelectric Point (pI)	4.45

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hgh1p (InterPro)
Physical Interactions	There are 18 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053035 \| P48362 MIPS: YGR187C NCBI: 1002516 \| 1323332 \| 1430953 \| 1708196 \| 398366069 \| NP_011703.3 \| NM_001181316.3 GenBank/EMBL/DDBJ: DAA08281.1 \| U27358 \| X99074 \| Z72972

Amino Acid Sequence (or in FASTA format)
1 MTSQLNELVE FLHSPQPAVR QIAIDNLVGF SAGPTSKVFK NDSYRPIKDI 51 IKMIMDPEHG TRVIIQQGVT ILVNLSEDKL VRNIILSDDK KFLKFLVWKI 101 VDLTNPNADI MCILLSNLAK DDGILAVLNI KRNSSGEEVD DGLKLAALNK 151 EVFKSLRAMD CLMDCFVKGY DKKLTKYASF NYLAFFFADI SRFKLGRMYF 201 IEEQEYDGVV PISKLLVFTE KYDAKVRREG VASTIKNSLF DSETHERLLK 251 DEKINLLPYI LLPIASAKDS EIDEEDMFNL PDELQLLPED KERDPIPAII 301 CCHLESILLL CTTHAGREYL RDKSVYPLVR ELHKNVENED IGELCYRIVN 351 MLMRGEPGAG AVEEMPSKNA EEEEEEESEE EEDDDEEDEI VEVA*

Amino Acid Sequence (or in FASTA format)

       1  MTSQLNELVE FLHSPQPAVR QIAIDNLVGF SAGPTSKVFK NDSYRPIKDI
      51  IKMIMDPEHG TRVIIQQGVT ILVNLSEDKL VRNIILSDDK KFLKFLVWKI
     101  VDLTNPNADI MCILLSNLAK DDGILAVLNI KRNSSGEEVD DGLKLAALNK
     151  EVFKSLRAMD CLMDCFVKGY DKKLTKYASF NYLAFFFADI SRFKLGRMYF
     201  IEEQEYDGVV PISKLLVFTE KYDAKVRREG VASTIKNSLF DSETHERLLK
     251  DEKINLLPYI LLPIASAKDS EIDEEDMFNL PDELQLLPED KERDPIPAII
     301  CCHLESILLL CTTHAGREYL RDKSVYPLVR ELHKNVENED IGELCYRIVN
     351  MLMRGEPGAG AVEEMPSKNA EEEEEEESEE EEDDDEEDEI VEVA*

external links for Hgh1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Hgh1p

1)	Arroyo J, et al. (1997) DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII. Yeast 13(4):357-63
2)	Rodriguez-Pena JM, et al. (1998) The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Yeast 14(9):853-60
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Wade CH, et al. (2006) The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Yeast 23(4):293-306
5)	Heinicke S, et al. (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2(8):e766
6)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41