RBG2/YGR173W Protein Information

Standard Name	Rbg2p 1
Systematic Name	Ygr173wp
Alias	Gir1p
ORF Classification	Verified
Description	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein (2, 3)
Name Description	RiBosome interacting Gtpase 4

Experimental Data
Molecules/cell	6200 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	368
Molecular Weight (Da)	41,006
Isoelectric Point (pI)	8.85

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rbg2p (InterPro)
Physical Interactions	There are 27 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AF8C \| P53295 MIPS: YGR173W NCBI: 1323306 \| 1723727 \| 6321612 \| NP_011689.1 GenBank/EMBL/DDBJ: DAA08268.1 \| Z72958

Amino Acid Sequence (or in FASTA format)
1 MGIIDKIKAI EEEMARTQKN KATEHHLGLL KGKLARYRQQ LLADEAGSGG 51 GGGSGFEVAK SGDARVVLIG YPSVGKSSLL GKITTTKSEI AHYAFTTLTS 101 VPGVLKYQGA EIQIVDLPGI IYGASQGKGR GRQVVATART ADLVLMVLDA 151 TKSEHQRASL EKELENVGIR LNKEKPNIYY KKKETGGVKV TFTSPPKTNL 201 TEQAIKMILR DYRIHNAEVL VRDDQCTIDD FIDVINEQHR NYVKCLYVYN 251 KIDAVSLEEV DKLAREPNTV VMSCEMDLGL QDVVEEIWYQ LNLSRVYTKK 301 RGVRPVFDDP LVVRNNSTIG DLCHGIHRDF KDKFKYALVW GSSAKHSPQK 351 CGLNHRIDDE DVVSLFAK*

Amino Acid Sequence (or in FASTA format)

       1  MGIIDKIKAI EEEMARTQKN KATEHHLGLL KGKLARYRQQ LLADEAGSGG
      51  GGGSGFEVAK SGDARVVLIG YPSVGKSSLL GKITTTKSEI AHYAFTTLTS
     101  VPGVLKYQGA EIQIVDLPGI IYGASQGKGR GRQVVATART ADLVLMVLDA
     151  TKSEHQRASL EKELENVGIR LNKEKPNIYY KKKETGGVKV TFTSPPKTNL
     201  TEQAIKMILR DYRIHNAEVL VRDDQCTIDD FIDVINEQHR NYVKCLYVYN
     251  KIDAVSLEEV DKLAREPNTV VMSCEMDLGL QDVVEEIWYQ LNLSRVYTKK
     301  RGVRPVFDDP LVVRNNSTIG DLCHGIHRDF KDKFKYALVW GSSAKHSPQK
     351  CGLNHRIDDE DVVSLFAK*

external links for Rbg2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rbg2p

1)	Datta K, et al. (2005) The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2. Mol Biol Cell 16(2):954-63
2)	Li B and Trueb B (2000) DRG represents a family of two closely related GTP-binding proteins. Biochim Biophys Acta 1491(1-3):196-204
3)	Daugeron MC, et al. (2011) The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1. Nucleic Acids Res 39(6):2221-33
4)	Wout PK, et al. (2009) Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Eukaryot Cell 8(7):1061-71
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41