CLC1/YGR167W Protein Information

Standard Name	Clc1p 1
Systematic Name	Ygr167wp
Alias	Scd4p 2, 3
ORF Classification	Verified
Description	Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W (1, 3, 4, 5, 6, 7)
Name Description	Clathrin Light Chain 1

Experimental Data
Molecules/cell	3490 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	233
Molecular Weight (Da)	26,531
Isoelectric Point (pI)	4.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Clc1p (InterPro)
Physical Interactions	There are 61 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F09 \| P17891 MIPS: YGR167W NCBI: 116499 \| 1323294 \| 1945336 \| 3545 \| 398365991 \| 45270434 \| NP_011683.3 \| NM_001181296.3 GenBank/EMBL/DDBJ: DAA08261.1 \| AY558272 \| X52272 \| Z72952 \| Z72953

Amino Acid Sequence (or in FASTA format)
1 MSEKFPPLED QNIDFTPNDK KDDDTDFLKR EAEILGDEFK TEQDDILETE 51 ASPAKDDDEI RDFEEQFPDI NSANGAVSSD QNGSATVSSG NDNGEADDDF 101 STFEGANQST ESVKEDRSEV VDQWKQRRAV EIHEKDLKDE ELKKELQDEA 151 IKHIDDFYDS YNKKKEQQLE DAAKEAEAFL KKRDEFFGQD NTTWDRALQL 201 INQDDADIIG GRDRSKLKEI LLRLKGNAKA PGA*

Amino Acid Sequence (or in FASTA format)

       1  MSEKFPPLED QNIDFTPNDK KDDDTDFLKR EAEILGDEFK TEQDDILETE
      51  ASPAKDDDEI RDFEEQFPDI NSANGAVSSD QNGSATVSSG NDNGEADDDF
     101  STFEGANQST ESVKEDRSEV VDQWKQRRAV EIHEKDLKDE ELKKELQDEA
     151  IKHIDDFYDS YNKKKEQQLE DAAKEAEAFL KKRDEFFGQD NTTWDRALQL
     201  INQDDADIIG GRDRSKLKEI LLRLKGNAKA PGA*

external links for Clc1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Clc1p

1)	Silveira LA, et al. (1990) Yeast clathrin has a distinctive light chain that is important for cell growth. J Cell Biol 111(4):1437-49
2)	Nelson KK and Lemmon SK (1993) Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol 13(1):521-32
3)	Huang KM, et al. (1997) Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast. J Cell Sci 110 ( Pt 7):899-910
4)	Chu DS, et al. (1999) A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae. Mol Biol Cell 10(3):713-26
5)	Chu DS, et al. (1996) The light chain subunit is required for clathrin function in Saccharomyces cerevisiae. J Biol Chem 271(51):33123-30
6)	Kirchhausen T (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98
7)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41