GTR2/YGR163W Protein Information

Standard Name	Gtr2p
Systematic Name	Ygr163wp
ORF Classification	Verified
Description	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD (1, 2, 3, 4, 5)
Name Description	GTp binding protein Resemblance 1

Experimental Data
Molecules/cell	2610 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	341
Molecular Weight (Da)	38,600
Isoelectric Point (pI)	4.41

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gtr2p (InterPro)
Physical Interactions	There are 39 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000005325F \| P53290 MIPS: YGR163W NCBI: 1323286 \| 1723722 \| 3219160 \| 344189684 \| 344189686 \| 398365979 \| 400261193 \| NP_011679.3 GenBank/EMBL/DDBJ: DAA08258.1 \| AB015239 \| Z72948

Amino Acid Sequence (or in FASTA format)
1 MSLEATDSKA MVLLMGVRRC GKSSICKVVF HNMQPLDTLY LESTSNPSLE 51 HFSTLIDLAV MELPGQLNYF EPSYDSERLF KSVGALVYVI DSQDEYINAI 101 TNLAMIIEYA YKVNPSINIE VLIHKVDGLS EDFKVDAQRD IMQRTGEELL 151 ELGLDGVQVS FYLTSIFDHS IYEAFSRIVQ KLIPELSFLE NMLDNLIQHS 201 KIEKAFLFDV NSKIYVSTDS NPVDIQMYEV CSEFIDVTID LFDLYKAPVL 251 RNSQKSSDKD NVINPRNELQ NVSQLANGVI IYLRQMIRGL ALVAIIRPNG 301 TDMESCLTVA DYNIDIFKKG LEDIWANARA SQAKNSIEDD V*

Amino Acid Sequence (or in FASTA format)

       1  MSLEATDSKA MVLLMGVRRC GKSSICKVVF HNMQPLDTLY LESTSNPSLE
      51  HFSTLIDLAV MELPGQLNYF EPSYDSERLF KSVGALVYVI DSQDEYINAI
     101  TNLAMIIEYA YKVNPSINIE VLIHKVDGLS EDFKVDAQRD IMQRTGEELL
     151  ELGLDGVQVS FYLTSIFDHS IYEAFSRIVQ KLIPELSFLE NMLDNLIQHS
     201  KIEKAFLFDV NSKIYVSTDS NPVDIQMYEV CSEFIDVTID LFDLYKAPVL
     251  RNSQKSSDKD NVINPRNELQ NVSQLANGVI IYLRQMIRGL ALVAIIRPNG
     301  TDMESCLTVA DYNIDIFKKG LEDIWANARA SQAKNSIEDD V*

external links for Gtr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Gtr2p

1)	Nakashima N, et al. (1999) Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152(3):853-67
2)	Sekiguchi T, et al. (2001) Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J Biol Chem 276(10):7246-57
3)	Dubouloz F, et al. (2005) The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19(1):15-26
4)	Gao M and Kaiser CA (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8(7):657-67
5)	Sekiguchi T, et al. (2008) Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 368(3):748-54
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41