ENP2/YGR145W Protein Information

Standard Name	Enp2p 1
Systematic Name	Ygr145wp
ORF Classification	Verified
Description	Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p (1, 2, 3)
Name Description	Essential Nuclear Protein 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	707
Molecular Weight (Da)	81,734
Isoelectric Point (pI)	6.54

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Enp2p (InterPro)
Physical Interactions	There are 74 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000158E9D5 \| P48234 MIPS: YGR145W NCBI: 1045251 \| 1323244 \| 1351819 \| 330443568 \| 347595681 \| NP_011661.2 GenBank/EMBL/DDBJ: DAA08236.2 \| X85807 \| Z72930

Amino Acid Sequence (or in FASTA format)
1 MVLKSTSAND VSVYQVSGTN VSRSLPDWIA KKRKRQLKND LEYQNRVELI 51 QDFEFSEASN KIKVSRDGQY CMATGTYKPQ IHVYDFANLS LKFDRHTDAE 101 NVDFTILSDD WTKSVHLQND RSIQFQNKGG LHYTTRIPKF GRSLVYNKVN 151 CDLYVGASGN ELYRLNLEKG RFLNPFKLDT EGVNHVSINE VNGLLAAGTE 201 TNVVEFWDPR SRSRVSKLYL ENNIDNRPFQ VTTTSFRNDG LTFACGTSNG 251 YSYIYDLRTS EPSIIKDQGY GFDIKKIIWL DNVGTENKIV TCDKRIAKIW 301 DRLDGKAYAS MEPSVDINDI EHVPGTGMFF TANESIPMHT YYIPSLGPSP 351 RWCSFLDSIT EELEEKPSDT VYSNYRFITR DDVKKLNLTH LVGSRVLRAY 401 MHGFFINTEL YDKVSLIANP DAYKDERERE IRRRIEKERE SRIRSSGAVQ 451 KPKIKVNKTL VDKLSQKRGD KVAGKVLTDD RFKEMFEDEE FQVDEDDYDF 501 KQLNPVKSIK ETEEGAAKRI RALTAAEESD EERIAMKDGR GHYDYEDEES 551 DEEESDDETN QKSNKEELSE KDLRKMEKQK ALIERRKKEK EQSERFMNEM 601 KAGTSTSTQR DESAHVTFGE QVGELLEVEN GKKSNESILR RNQRGEAELT 651 FIPQRKSKKD GNYKSRRHDN SSDEEGIDEN GNKKDNGRSK PRFENRRRAS 701 KNAFRGM*

Amino Acid Sequence (or in FASTA format)

       1  MVLKSTSAND VSVYQVSGTN VSRSLPDWIA KKRKRQLKND LEYQNRVELI
      51  QDFEFSEASN KIKVSRDGQY CMATGTYKPQ IHVYDFANLS LKFDRHTDAE
     101  NVDFTILSDD WTKSVHLQND RSIQFQNKGG LHYTTRIPKF GRSLVYNKVN
     151  CDLYVGASGN ELYRLNLEKG RFLNPFKLDT EGVNHVSINE VNGLLAAGTE
     201  TNVVEFWDPR SRSRVSKLYL ENNIDNRPFQ VTTTSFRNDG LTFACGTSNG
     251  YSYIYDLRTS EPSIIKDQGY GFDIKKIIWL DNVGTENKIV TCDKRIAKIW
     301  DRLDGKAYAS MEPSVDINDI EHVPGTGMFF TANESIPMHT YYIPSLGPSP
     351  RWCSFLDSIT EELEEKPSDT VYSNYRFITR DDVKKLNLTH LVGSRVLRAY
     401  MHGFFINTEL YDKVSLIANP DAYKDERERE IRRRIEKERE SRIRSSGAVQ
     451  KPKIKVNKTL VDKLSQKRGD KVAGKVLTDD RFKEMFEDEE FQVDEDDYDF
     501  KQLNPVKSIK ETEEGAAKRI RALTAAEESD EERIAMKDGR GHYDYEDEES
     551  DEEESDDETN QKSNKEELSE KDLRKMEKQK ALIERRKKEK EQSERFMNEM
     601  KAGTSTSTQR DESAHVTFGE QVGELLEVEN GKKSNESILR RNQRGEAELT
     651  FIPQRKSKKD GNYKSRRHDN SSDEEGIDEN GNKKDNGRSK PRFENRRRAS
     701  KNAFRGM*

external links for Enp2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Enp2p

1)	Bernstein KA, et al. (2004) The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell 3(6):1619-26
2)	Coic E, et al. (2000) Evidence for short-patch mismatch repair in Saccharomyces cerevisiae. EMBO J 19(13):3408-17
3)	Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213