SKN1/YGR143W Protein Information Help

Standard Name Skn1p 1
Systematic Name Ygr143wp
ORF Classification Verified
Description Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Suppressor of Kre Null 1
Experimental Data
Molecules/cell 468 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 771
Molecular Weight (Da) 86,240
Isoelectric Point (pI) 4.52

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Skn1p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052E1E | P33336
MIPS: YGR143W
NCBI: 1323240 | 311157 | 398365875 | 464765 | NP_011659.3
GenBank/EMBL/DDBJ: DAA08234.1 | L18859 | Z72928
Amino Acid Sequence (or in FASTA format)
 
       1  MSVRNLTNNR HSNSENSVSG SENSFYSSNE QSRQSSSLEP ADGQNVRVSG
      51  NPFLGSEEFD EDYNSPSGDD ERRGANEYSS SSSINYNNDP NSDTSLLANE
     101  KNSPERNGQR MSDYKGYYAK TNLTSANNLN NHNNNNYKNI ISSSNDNSFA
     151  SHLQPPDRNL PSHPSSNNMS SFSNNSLIKS PPPFDRYPLV GTRHISAAQS
     201  QSQNLINEKK RANMTGSSSS AHDSSLSSTN LYMGEQDFSP FGGYPASFFP
     251  LTLDEKEDDD YIHNPNVEEE AKLDRRRFVD DFKHMDRRSF LGLLGILFLF
     301  MAGIFIFIVL PAITFSGVVY HHEHVHAANS AGSSSSNTTS KSLTEYQYPQ
     351  LAAIRTTLVD PDTPDSAKTR VAKDGSKWQL VFSDEFNAEG RTFYDGDDQF
     401  WTAPDIHYDA TKDLEWYSPD AVTTTNGTLT LRMDAFRNHD LYYRSGMVQS
     451  WNKLCFTEGA LEVSANLPNY GRVTGLWPGM WTMGNLGRPG YLASTQGVWP
     501  YSYEACDAGI TPNQSSPDGI SYLPGQKLSV CTCDNEDHPN QGVGRGAPEI
     551  DILEGEADTI LGVGVASQSL QIAPFDIWYM PDYDFIEVYN FTTTTMNTYA
     601  GGPFQQAVSA ISTLNVTWYE FGEEAGYFQK YAIEYLNDDD NGYIRWFVGE
     651  NPTFTLYATS LHPSGNIDWR RISKEPMSAI LNLGISNNWA YIDWQYIFFP
     701  VTMSIDYVRL YQPKGSTSIT CDPEDYPTYD YIQSHLNAYY NANLTDWEQA
     751  GYTFPKNILT GGCSSSKFSL S*

external links for Skn1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Skn1p
1) Roemer T, et al.  (1993) SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Mol Cell Biol 13(7):4039-48
2) Montijn RC, et al.  (1999) Localization of synthesis of beta1,6-glucan in Saccharomyces cerevisiae. J Bacteriol 181(24):7414-20
3) Thevissen K, et al.  (2005) SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. FEBS Lett 579(9):1973-7
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41