BTN2/YGR142W Protein Information

Standard Name	Btn2p
Systematic Name	Ygr142wp
ORF Classification	Verified
Description	v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	BaTteN disease 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	410
Molecular Weight (Da)	47,167
Isoelectric Point (pI)	4.93

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Btn2p (InterPro)
Physical Interactions	There are 36 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C53 \| P53286 MIPS: YGR142W NCBI: 1323238 \| 1723718 \| 398365869 \| NP_011658.3 \| NM_001181271.3 GenBank/EMBL/DDBJ: DAA08233.1 \| Z72927

Amino Acid Sequence (or in FASTA format)
1 MFSIFNSPCV FEQLPSFSQP LHSRYFDCSS PVSYYPECKR RKAIKANLRA 51 PKKSDANCSE PLRYALAETP NGYTLSLSKR IPYELFSKYV NEKLGELKEN 101 HYRPTYHVVQ DFFGNQYYVE DEADEDALLR SALKDLDFRA IGKKIAKDLF 151 QDYEIELNHR GDELSILSKK DKIFKEFSLD QVFEDVFVIG CGVENIDDGS 201 REKYALLKIG LVKHEEEISE GGINEPKMPI IESKIDESHD DVNMSESLKE 251 EEAEKAKEPL TKEDQIKKWI EEERLMQEES RKSEQEKAAK EDEERQKKEK 301 EARLKARKES LINKQKTKRS QQKKLQNSKS LPISEIEASN KNNNSNSGSA 351 ESDNESINSD SDTTLDFSVS GNTLKKHASP LLEDVEDEEV DRYNESLSRS 401 PKGNSIIEEI *

Amino Acid Sequence (or in FASTA format)

       1  MFSIFNSPCV FEQLPSFSQP LHSRYFDCSS PVSYYPECKR RKAIKANLRA
      51  PKKSDANCSE PLRYALAETP NGYTLSLSKR IPYELFSKYV NEKLGELKEN
     101  HYRPTYHVVQ DFFGNQYYVE DEADEDALLR SALKDLDFRA IGKKIAKDLF
     151  QDYEIELNHR GDELSILSKK DKIFKEFSLD QVFEDVFVIG CGVENIDDGS
     201  REKYALLKIG LVKHEEEISE GGINEPKMPI IESKIDESHD DVNMSESLKE
     251  EEAEKAKEPL TKEDQIKKWI EEERLMQEES RKSEQEKAAK EDEERQKKEK
     301  EARLKARKES LINKQKTKRS QQKKLQNSKS LPISEIEASN KNNNSNSGSA
     351  ESDNESINSD SDTTLDFSVS GNTLKKHASP LLEDVEDEEV DRYNESLSRS
     401  PKGNSIIEEI *

external links for Btn2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Btn2p

1)	Chattopadhyay S, et al. (2000) The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis. J Bacteriol 182(22):6418-23
2)	Chattopadhyay S and Pearce DA (2002) Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae. Eukaryot Cell 1(4):606-12
3)	Chattopadhyay S, et al. (2003) The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p. Biochem Biophys Res Commun 302(3):534-8
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Kama R, et al. (2007) Btn2, a hook1 ortholog and potential batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast. Mol Cell Biol 27(2):605-21
6)	Pearce DA, et al. (1999) Action of BTN1, the yeast orthologue of the gene mutated in Batten disease. Nat Genet 22(1):55-8