PEX4/YGR133W Protein Information

Standard Name	Pex4p 1
Systematic Name	Ygr133wp
Alias	Pas2p 2 , Ubc10p 3
ORF Classification	Verified
Description	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis (2, 3, 4, 5)
Name Description	PEroXin 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	183
Molecular Weight (Da)	21,118
Isoelectric Point (pI)	5.36

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pex4p (InterPro)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000137977 \| P29340 MIPS: YGR133W NCBI: 1323221 \| 136649 \| 354459468 \| 378791963 \| 378791965 \| 4101 \| 45269443 \| 6321572 \| NP_011649.1 GenBank/EMBL/DDBJ: DAA08226.1 \| AY557776 \| X65470 \| Z72918
External Classifications	EC: 6.3.2.19 [Ubiquitin--protein ligase]

Amino Acid Sequence (or in FASTA format)
1 MPNFWILENR RSYTSDTCMS RIVKEYKVIL KTLASDDPIA NPYRGIIESL 51 NPIDETDLSK WEAIISGPSD TPYENHQFRI LIEVPSSYPM NPPKISFMQN 101 NILHCNVKSA TGEICLNILK PEEWTPVWDL LHCVHAVWRL LREPVCDSPL 151 DVDIGNIIRC GDMSAYQGIV KYFLAERERI NNH*

Amino Acid Sequence (or in FASTA format)

       1  MPNFWILENR RSYTSDTCMS RIVKEYKVIL KTLASDDPIA NPYRGIIESL
      51  NPIDETDLSK WEAIISGPSD TPYENHQFRI LIEVPSSYPM NPPKISFMQN
     101  NILHCNVKSA TGEICLNILK PEEWTPVWDL LHCVHAVWRL LREPVCDSPL
     151  DVDIGNIIRC GDMSAYQGIV KYFLAERERI NNH*

external links for Pex4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Pex4p

1)	Distel B, et al. (1996) A unified nomenclature for peroxisome biogenesis factors. J Cell Biol 135(1):1-3
2)	Erdmann R, et al. (1989) Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 86(14):5419-23
3)	Wiebel FF and Kunau WH (1992) The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature 359(6390):73-6
4)	Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34
5)	Kragt A, et al. (2005) The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J Biol Chem 280(9):7867-74