RPS23A/YGR118W Protein Information Help

Standard Name Rps23ap
Systematic Name Ygr118wp
ORF Classification Verified
Description Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal (1, 2, 3, 4, 5, 6)
Name Description Ribosomal Protein of the Small subunit
Gene Product S12 6 , S23A 7 , S28A 7 , YS14 7 , rp37 7
Experimental Data
Molecules/cell 10600 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 145
Molecular Weight (Da) 16,038
Isoelectric Point (pI) 11.47

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rps23ap (InterPro)
Physical Interactions There are 44 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000004F6D | P0CX29
MIPS: YGR118W
NCBI: 1323191 | 172498 | 338819288 | 398365761 | 49258831 | 6325389 | NP_011633.3 | NP_015457.1 | NM_001181247.3 | NM_001184229.1
GenBank/EMBL/DDBJ: AAA16235.1 | CAA97128.1 | DAA08210.1 | M96570 | Z72903
Amino Acid Sequence (or in FASTA format)
       1  MGKGKPRGLN SARKLRVHRR NNRWAENNYK KRLLGTAFKS SPFGGSSHAK
      51  GIVLEKLGIE SKQPNSAIRK CVRVQLIKNG KKVTAFVPND GCLNFVDEND
     101  EVLLAGFGRK GKAKGDIPGV RFKVVKVSGV SLLALWKEKK EKPRS*    

external links for Rps23ap
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY GeneMANIA YeastRC Structure Prediction (Seattle)

IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rps23ap
1) Synetos D, et al.  (1996) Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Biochim Biophys Acta 1309(1-2):156-66
2) Anthony RA and Liebman SW  (1995) Alterations in ribosomal protein RPS28 can diversely affect translational accuracy in Saccharomyces cerevisiae. Genetics 140(4):1247-58
3) Alksne LE and Warner JR  (1993) A novel cloning strategy reveals the gene for the yeast homologue to Escherichia coli ribosomal protein S12. J Biol Chem 268(15):10813-9
4) Lecompte O, et al.  (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Jenner L, et al.  (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
7) Planta RJ and Mager WH  (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41