TOM20/YGR082W Protein Information

Standard Name	Tom20p 1
Systematic Name	Ygr082wp
Alias	Mas20p 2 , Mom19p 3
ORF Classification	Verified
Description	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins (4, 5, 6, 7)
Name Description	Translocase of the Outer Mitochondrial membrane 1

Experimental Data
Molecules/cell	5680 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	183
Molecular Weight (Da)	20,317
Isoelectric Point (pI)	5.49

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tom20p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 47 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000130CA7 \| P35180 MIPS: YGR082W NCBI: 1323117 \| 406600 \| 45269441 \| 453432 \| 464308 \| 6321519 \| NP_011596.1 GenBank/EMBL/DDBJ: DAA08175.1 \| AY557775 \| X75319 \| X76139 \| Z72867

Amino Acid Sequence (or in FASTA format)
1 MSQSNPILRG LAITTAIAAL SATGYAIYFD YQRRNSPQFR KVLRQRAKEQ 51 AKMEEQAKTH AKEVKLQKVT EFLSMELAKD PIPSDPSERE ATFTTNVENG 101 ERLSMQQGKE LEAASKFYKA LTVYPQPADL LGIYQRSIPE AIYEYIILMI 151 AILPPANVAS FVKGVVGSKA ESDAVAEAND IDD*

Amino Acid Sequence (or in FASTA format)

       1  MSQSNPILRG LAITTAIAAL SATGYAIYFD YQRRNSPQFR KVLRQRAKEQ
      51  AKMEEQAKTH AKEVKLQKVT EFLSMELAKD PIPSDPSERE ATFTTNVENG
     101  ERLSMQQGKE LEAASKFYKA LTVYPQPADL LGIYQRSIPE AIYEYIILMI
     151  AILPPANVAS FVKGVVGSKA ESDAVAEAND IDD*

external links for Tom20p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Tom20p

1)	Pfanner N, et al. (1996) Uniform nomenclature for the protein transport machinery of the mitochondrial membranes. Trends Biochem Sci 21(2):51-2
2)	Ramage L, et al. (1993) Functional cooperation of mitochondrial protein import receptors in yeast. EMBO J 12(11):4115-23
3)	Moczko M, et al. (1993) The protein import receptor MOM19 of yeast mitochondria. FEBS Lett 326(1-3):251-4
4)	Meisinger C, et al. (1999) The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore. Cell Mol Life Sci 56(9-10):817-24
5)	Ryan MT, et al. (2000) The transport machinery for the import of preproteins across the outer mitochondrial membrane. Int J Biochem Cell Biol 32(1):13-21
6)	Pfanner N, et al. (2004) Assembling the mitochondrial outer membrane. Nat Struct Mol Biol 11(11):1044-8
7)	Likic VA, et al. (2005) Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. J Mol Biol 347(1):81-93
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41