ENV11/YGR071C Protein Information Help

Standard Name Env11p 1
Systematic Name Ygr071cp
ORF Classification Verified
Description Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description late ENdosome and Vacuole interface function 1
Experimental Data
Molecules/cell 1050 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 860
Molecular Weight (Da) 98,108
Isoelectric Point (pI) 5.83

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Env11p (InterPro)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013AF55 | P53246
MIPS: YGR071C
NCBI: 1323097 | 1723679 | 398365511 | NP_011585.3
GenBank/EMBL/DDBJ: DAA08165.1 | Z72856
Amino Acid Sequence (or in FASTA format)
 
       1  MNTALDDLHG DLVTLEDNEI INNSDHSSSH STSHEEEDEE EDDTEDIELI
      51  EKDGNKILSS RIHPEDEIIN DGLNIWIPVQ MLKKNIAKFW SHFLAIEKKL
     101  TKVKCKHCGE ILTRSDASLT KTFRSHLKTK HNISANKNFY SMNFTVGDSN
     151  LKNNTSSTEI TRRHGYDSLT FNSDQSFKCF DIGKLQSSNY LSISQLVAIV
     201  IASENLPLNF FENVSFKSLL SKFHRIPPLT TNIIEESIIG LSKSIDELIR
     251  RSISRNDTQL PFTIHLSDSK ESNQPLYLKY SREIRAQLSN LDLSHLISVN
     301  FTELAGKRSL FSLQLFDNTN KVSKGLPLSI FVRKTTDIDI SVWQEQLNNL
     351  YSKYPGLQKS VISITLPQSH YTMVLENRNS HNFTFHSGSV REIKYHTCIV
     401  SELLHCFLQP LFNVPTESML SSFSVAKENH SGGSLLDSLI DFSHIDLSST
     451  ILGKICCLIE EVNLNDSLKS DFLLYCQNYT QPNCNELTSI LSCNCDRFSA
     501  LKSILEKFAN LVPFFKSINS HLENESLSES DFRLINTVEE TLRTFEQSIE
     551  YFASSAPLKF THTLVFIIKF ELYLTEIIRS FKFTKSKKPF EKILARLLKV
     601  KDLYLLDDVN LIGAFLYPSI FQSKSLLNEI FGTTSVNKIV HNMTKIVLRY
     651  LKNFINITNF RSSNSGGESG RNSGNNLLSD YEAIFMKESR DVELLCNTKL
     701  TAPLTEDSLL VQIIRDDLLR YVNRIAHELP NAYHDYLNDN DISFDGSHFT
     751  KHELSEENDS NSGEWCLNPM EETFDIHIPI SDSIWNNYIS SKNKIEVIDI
     801  LLQLLSVNST SSIRSELSSL TANQDFSTKL SEETIKIKLL NSQFNLEKIN
     851  FHSGSIFDAC *

external links for Env11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Env11p
1) Ricarte F, et al.  (2011) A Genome-Wide Immunodetection Screen in S. cerevisiae Uncovers Novel Genes Involved in Lysosomal Vacuole Function and Morphology. PLoS One 6(8):e23696
2) Wilson WA, et al.  (2002) Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Mol Cell Proteomics 1(3):232-42
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Watanabe M, et al.  (2009) Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth. Curr Genet 55(4):365-80
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41