VHT1/YGR065C Protein Information Help

Standard Name Vht1p 1
Systematic Name Ygr065cp
ORF Classification Verified
Description High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin (1, 2)
Name Description Vitamin H Transporter 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 593
Molecular Weight (Da) 69,082
Isoelectric Point (pI) 9.34

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vht1p (InterPro)
Transmembrane Domains There are 10 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001387BB | P53241
MIPS: YGR065C
NCBI: 1323086 | 1723674 | 6321502 | NP_011579.1
GenBank/EMBL/DDBJ: DAA08160.1 | Z72850
External Classifications TC: 2.A.1.14 [The Anion: Cation Symporter (ACS) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MTISNKSWRS YFPHLRKLPE DDQYLYSDDT NSSIIAEEEL HHSVDKSSKT
      51  DVTAETTAVE PHPHNLRHDL PYEVRDEAGR KWWKYFDEFE YRVNKEYKKS
     101  RKWYEFLYPN HTTQTKAERR LLYKLDIIIA LYFFMLCWSK SVDLNNYTNA
     151  YVSNMKEDLN MKGNDYVYTS TIANVGAIVF QLPFMYLLPR FPSHIILPVM
     201  DLGWTWFTFA CYRANSLAEL RAYRFILSAF GAAYYPVSQY ILGCWYAPDE
     251  INSRVCLFFC GQQLGSVTSG LLQSRIFKSL NGVHGLAGWR WMFLIDAIAI
     301  SLPTAIIGFF VIPGVPSKCY SLFLTDEEIR IARARNKRNQ IKDGVDKSKL
     351  APLWSRKLWK KVFCTPAFWV LVVFDTCSWN NMTAYSGSYT LWLKSNTKYS
     401  IAQVNNLSVI PACLGFAYVI FCAFGADLFR CKWIFMVFAA IMNTVSCALL
     451  IKWDIPSKAK WYAFFTTYFS VAASPCLWSF INDFLRFDPQ VKAITWIAIY
     501  SFSQSTYAWI PTLAWPTVES PRFKTGYTVS LIFGAIYGLW TFVVLFFYKR
     551  NEKKHALGNG IILYDSNKGE ELPEFVKKNM EERDGYYYLK RSS*

external links for Vht1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Vht1p
1) Stolz J, et al.  (1999) Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant. J Biol Chem 274(26):18741-6
2) Shakoury-Elizeh M, et al.  (2004) Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Mol Biol Cell 15(3):1233-43