RME1/YGR044C Protein Information

Standard Name	Rme1p 1
Systematic Name	Ygr044cp
Alias	Csp1p
ORF Classification	Verified
Description	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress (2, 3, 4)
Name Description	Regulator of MEiosis 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	300
Molecular Weight (Da)	33,904
Isoelectric Point (pI)	7.08

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rme1p (InterPro)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001342F5 \| P32338 \| B8XW41 MIPS: YGR044C NCBI: 417688 \| 6321481 \| NP_011558.1 GenBank/EMBL/DDBJ: DAA08143.1 \| DQ116799 \| DQ116801 \| DQ116802 \| DQ116804 \| DQ116805 \| DQ116806 \| DQ116807 \| M76447 \| Z72829

Amino Acid Sequence (or in FASTA format)
1 MSPCYGQNSA IAKGSWNREV LQEVQPIYHW HDFGQNMKEY SASPLEGDSS 51 LPSSLPSSTE DCLLLSLENT ITVIAGNQRQ AYDSTSSTEE GTAPQLRPDE 101 IADSTHCITS LVDPEFRDLI NYGRQKGANP VFIESNTTEQ SHSQCILGYP 151 QKSHVAQLYH DPKVLSTISE GQTKRGSYHC SHCSEKFATL VEFAAHLDEF 201 NLERPCKCPI EQCPWKILGF QQATGLRRHC ASQHIGELDI EMEKSLNLKV 251 EKYPGLNCPF PICQKTFRRK DAYKRHVAMV HNNADSRFNK RLKKILNNTK 301 *

Amino Acid Sequence (or in FASTA format)

       1  MSPCYGQNSA IAKGSWNREV LQEVQPIYHW HDFGQNMKEY SASPLEGDSS
      51  LPSSLPSSTE DCLLLSLENT ITVIAGNQRQ AYDSTSSTEE GTAPQLRPDE
     101  IADSTHCITS LVDPEFRDLI NYGRQKGANP VFIESNTTEQ SHSQCILGYP
     151  QKSHVAQLYH DPKVLSTISE GQTKRGSYHC SHCSEKFATL VEFAAHLDEF
     201  NLERPCKCPI EQCPWKILGF QQATGLRRHC ASQHIGELDI EMEKSLNLKV
     251  EKYPGLNCPF PICQKTFRRK DAYKRHVAMV HNNADSRFNK RLKKILNNTK
     301  *

external links for Rme1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Rme1p

1)	Kassir Y and Simchen G (1976) Regulation of mating and meiosis in yeast by the mating-type region. Genetics 82(2):187-206
2)	Covitz PA, et al. (1991) The yeast RME1 gene encodes a putative zinc finger protein that is directly repressed by a1-alpha 2. Genes Dev 5(11):1982-9
3)	Rine J, et al. (1981) rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation. Mol Cell Biol 1(10):958-60
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76